摘要
目的利用扩散张量成像（DTI）各向异性分数（FA）熵值定量分析脊髓型颈椎病（CSM）患者颈髓损伤情况。方法2014年3月至2015年3月收集24例CSM患者（CSM组）和24名性别、年龄相匹配的健康志愿者（对照组）行颈髓DTI扫描，分别测量不同椎体及椎间盘对应的颈髓层面（横断面）全脊髓（含灰质和白质）的FA值，以全脊髓横断面为ROI，提取ROI内每个体素FA值，进一步计算其香农熵值，用于评价CSM患者颈髓结构的紊乱程度。两组间FA值及其熵值的比较采用两独立样本t检验分析。结果CSM组全颈髓FA值为0．644±0．056，对照组FA值为0．672±0．035，两组间FA值差异有统计学意义（t=-2．049，P=0．046）。CSM组全颈髓FA熵值为0．687±0．043，对照组为0．854±0．027，CSM组FA熵值较对照组显著降低，差异具有统计学意义（t=-12．100，P〈0．001）。CSM组和对照组层间仅有C6层面FA值差异有统计学意义，其他层面两组间FA值差异均无统计学意义。CSM组患者每一层面颈髓FA熵值均较对照组明显减小，差异具有统计学意义。结论CSM患者颈髓的FA熵值明显降低，表明FA熵值可以用于探测CSM患者颈髓损伤。
Objective To quantitative analyze the injury degree of cervical cord in cervical spondylotic myelopathy （CSM） patients using fractional anisotropy （FA） entropy of diffusion tensor imaging （DTI）. Methods Twenty-four CSM patients and well-match healthy volunteers underwent cervical cord DTI scanning. FA value was measured at each segment of spinal cord （including grey matter and white matter） of spinal cord level and intervertebral disc level. Further Shannon entropy of FA value was calculated in each segment to observe the disorder degree of cervical cord structure in CSM patients. After the analysis of homogeneity of variance, two samples t test analysis was used to identify FC＇s differences of FA and Shannon entropy of FA value between the two groups. Result In CSM group, the average FA value of whole cervical cord was 0.644 ± 0.056, while it was 0.672 ± 0.035 in the healthy control group. There was significant difference of FA values between the two groups （t= - 2.049, P=0.046）. The FA entropy of CSM patients＇ cervical cord was 0.687±0.043, while it was 0.854±0.027 in the healthy control group. The FA entropy of CSM patients＇ cervical cord was lower than that of control group. There was significant difference of FA entropy between the two groups （t=-12.100, P〈0.001）. The significant difference between the two groups was only found at C6 level for each level＇s FA value. The FA entropy of CSM patients＇ cervical cord was significantly lower than that of control group for every level. Conclusion This decreased FA entropy of cervical cord in CSM patients indicates that FA entropy can be used to detect the disorder of cervical cord structure in CSM patients.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2016年第8期571-575,共5页
Chinese Journal of Radiology
基金
国家自然科学基金（81460329）
关键词
脊髓型颈椎病
磁共振成像
Cervical spondylotic myelopathy
Magnetic resonance imaging
