摘要
目的探讨磁共振扩散张量成像(Diffusion Tensor Imaging,DTI)序列的测量数值及神经纤维束损害程度与脊髓型颈椎病患者临床表现的相关性。方法回顾性分析2018年9月至2019年8月在本院检查的52位颈椎病患者病例资料,均行常规MRI序列、DTI序列及3D-BRAVO序列扫描。根据患者的临床表现进行日本骨科学会(Japanese Orthopaedic Association,JOA)评分,分为轻度组、中度组和重度组。利用SPSS分析三组颈部受压段颈髓各项异性分数(Fractional Anisotropy,FA)和表观扩散系数(Apparent Diffusion Coefficient,ADC)之间的统计学意义,利用Spearman分析方法来观察JOA数值与DTI测量数据的相关性。结果轻度、中度和重度三组受压段脊髓测量的FA值分别为0.65±0.03、0.51±0.03、0.42±0.02,比较具有显著差异(F=290.44,P<0.05)。三组ADC数值分别为1.02±0.14、1.30±0.25、1.19±0.29,比较具有显著差异(F=10.509,P<0.05)。方差齐性检验FA值显著性为0.097(P>0.05),选用最小显著差值法,两两比较差异均有统计学意义(P<0.05),ADC值因方差齐性检验显著性为0.013(P<0.05)。各组的JOA评分数值和平均FA数值具有正相关性(r=0.972,P<0.05)。结论DTI测量的FA数值与临床FOA评分成正相关,FA数值越高,颈髓纤维束损害越低,由此,DTI纤维束成像能更为直观地显示颈髓纤维束的受损情况。
Objective To investigate the correlation between the measurement value of diffusion tensor imaging(DTI)sequence and the degree of nerve fiber tract damage with clinical manifestations of cervical spondylotic myelopathy.Methods The clinical data of 52 patients with cervical spondylosis in our hospital from September 2018 to August 2019 were retrospectively analyzed.All patients underwent conventional MRI sequence,DTI sequence and 3D-BRAVO sequence scanning.According to the clinical manifestations of the patients,the Japanese Orthopaedic Association(JOA)score was made and divided into mild group,moderate group and severe group.SPSS was used to analyze the statistical significance of fractional anisotropy(FA)and apparent diffusion coefficient(ADC)in the three groups.Spearman analysis was used to observe the correlation between JOA and DTI data.Results The measured FA values of the spinal cord in the three groups of mild,moderate and severe compression were 0.65±0.03,0.51±0.03,0.42±0.02,which were significantly different(F=290.44,P<0.05).The ADC values of the three groups were 1.02±0.14,1.30±0.25,1.19±0.29,and there were significant differences in comparison(F=10.509,P<0.05).The FA value of the test for homogeneity of variance was significant 0.097(P>0.05),and the least significant difference method was selected,and the difference between the two comparisons was statistically significant(P<0.05),and the significance of the ADC value due to the homogeneity of variance test was 0.013(P<0.05).There was a positive correlation between the JOA score value and the average FA value of each group(r=0.972,P<0.05).Conclusion The FA value measured by DTI is positively correlated with the clinical FOA score.The higher the FA value,the lower the damage to the cervical spinal cord fiber bundle.Therefore,DTI fiber bundle imaging can more intuitively display the damage of the cervical cord fiber bundle.
作者
张浩
张雪
胡萧尹
张英
苗重昌
ZHANG Hao;ZHANG Xue;HU Xiaoyin;ZHANG Ying;MIAO Chongchang(Department of Imaging,Lianyungang Hospital Affiliated to Xuzhou Medical University,Lianyungang Jiangsu 222061,China)
出处
《中国医疗设备》
2020年第11期113-117,共5页
China Medical Devices
