摘要
目的探讨3.0 TMR 扩散张量成像(DTI)作为一种定量分析方法在颈椎病中的应用价值。方法 21名健康志愿者(对照组)和84例颈椎病患者行颈髓 DTI,根据 T_2WI 表现将颈椎病组分为 A(单纯硬膜囊受压)、B(颈髓轻度受压)、C(颈髓受压,T_2WI 可疑高信号)、D(颈髓受压,T_2WI信号增高)4组,每组21例,以健康组为对照,分析颈椎病组表观扩散系数(ADC)、分数各向异性(FA)值及本征(λ_1、λ_2、λ_3)值的变化,对所有受检者行颈髓纤维束成像。结果所有受检者 DTI 显示满意。21名对照组颈髓平均 ADC 值为(0.78±0.08)×10^(-3)mm^2/s,FA值为0.72±0.03,λ_1、λ_2、λ_3值分别为(1.51±0.15)×10^(-3)mm^2/s、(0.42±0.09)×10^(-3)mm^2/s、(0.41±0.10)×10^(-3)mm^2/s。对照组与硬膜囊受压组比较,ADC(q=1.451)、FA(q=1.999)、λ_1(q=1.137)值差异无统计学意义(P 值均>0.05),与λ_2(q=3.039)、λ_3(q=2.982)值差异存在统计学意义(P 值均<0.05)。对照组与 B、C、D 3个颈髓受压组比较,ADC 值的 q 值分别为7.982、8.532、14.073,FA 值的 q 值分别为12.206、15.889、26.306,λ_1 值的 q 值分别为4.601、4.845、6.631,入_2值的 q 值分别为6.502、11.060、20.480,λ_3值的 q 值分别为9.782、9.416、16.949,差异均存在统计学意义(P 值均<0.01)。结论 ADC、FA、λ_1、λ_2、λ_3值是检测颈髓微结构改变的敏感指标。
Objective To evaluate the application of the diffusion tensor imaging （DTI） as a quantitative tool in cervical spondylosis with 3.0 T MR. Methods Twenty-one healthy volunteers and 84 patients with cervical spondylosis were performed T2WI and DTI by using a 3.0 T MR scanner. Eighty- four patients were divided into 4 groups according to the compressive degree of cervical spinal cord on T2WI. Group A had only the dura mater spinalis compressed; Group B showed the cervical spinal cord compressed, but no high signal in it. Group C had the cervical spinal cord compressed with suspected high signal in the same level. Group D showed the cervical spinal cord compressed with high signal. ADC, FA, hi, k2 and ha values of these examinee were analyzed with a software package of SPSS 11.0. Fiber tracking was performed in these examinee with functool software of GE Company. Results High quality ADC maps, FA maps and fiber tracking of cervical spinal cord were obtained in all cases. For healthy people, averaged ADC, FA, λ1 , λ2 and λ3 values were （0. 78 ± 0. 08 ） × 10^-3 mm^2/s, 0. 72 ±0. 03, （ 1.51 ± 0. 15 ） × 10^-3 mm^2/s, （0. 42 ~ 0. 09 ）× 10^-3 mm^2/s and （ 0. 41 ± 0. 10 ） × 10^-3 mm^2/s, respectively. Between the control group and the group A, there were no statistically significant differences in ADC （q = 1.451, P 〉 0. 05 ） , FA （q = 1. 999, P 〉 0. 05 ） and hi （q = 1. 137, P 〉 0. 05 ）. There were significant differences in λ2 （q = 3. 039, P 〈 0. 05 ） and λ3 （ q = 2. 982, P 〈 0. 05 ）. There were significant differences in ADC, FA, λ1 , λ2 and k3 （ P 〈 0.01 ） between the control group and group B（ ADC =7.982, FA = 12. 206, λ1 =4.601, λ2 = 6.502, λ3 = 9. 782） , between the control group and group C（ ADC = 8. 532, FA = 15. 889, λ1 =4. 845, λ2 = 11. 060, λ3 =9. 416）, between the control group and group D （ ADC = 14. 073, FA = 26. 306, λ1 = 6. 631, λ2 = 20. 480, λ3 = 16. 949 ）, respectively. Condusion ADC, FA, λ1,λ2 and λ3 values are s
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2007年第12期1314-1319,共6页
Chinese Journal of Radiology
基金
山东省自然科学基金(Y2004C11)
关键词
颈椎病
磁共振成像
弥散
Cervical spondylosis
Diffusion magnetic resonance imaging
