摘要
目的 :观察美洛昔康的抗炎作用。方法 :采用大鼠急性、亚急性及免疫性炎症模型 ,观察美洛昔康对角叉菜胶致大鼠足跖肿胀和大鼠棉球肉芽肿的影响以及美洛昔康对大鼠佐剂性关节炎的预防和治疗作用。结果 :美洛昔康对多种致炎剂引起的炎性水肿均具有明显的抑制作用 ,1.0和 3 .0mg·kg-1的美洛昔康对角叉菜胶致大鼠足跖肿胀均具有显著的抑制作用 ,作用持续至致炎后 2 4h ;对大鼠棉球肉芽肿也具有显著的抑制作用 ,抑制率分别为 36 .5 9%和 5 2 .34%。美洛昔康对大鼠佐剂性关节炎具有显著的预防和治疗作用 ,并能显著改善免疫性炎症引起的动物骨关节病理组织学变化。结论
Objective:To study the antiinflammatory effect of meloxicam in animals.Methods:3 kinds of animal model for experimental inflammation,including carrageenin induced paw edema,cotton ball granuloma and adjuvant induced arthritis,were adopted to validate the antiinflammable effect of meloxicam.Results:Meloxicam showed a marked inhibitory effect on carrageenin induced paw edema and cotton ball granuloma in rats,the inhibitory rate of meloxicam at the dose of 1.0,3.0mg·kg -1 in granuloma model were 36.59% and 52.34% respectively.In addition,meloxicam also showed a significant therapeutic effect on adjuvant induced arthritis in rats and improved the pathological changes of the induced athritis.Conclusion:Meloxicam shows significant antiinflammatory effects on animal models mentioned above. [
出处
《中国新药杂志》
CAS
CSCD
北大核心
2001年第5期345-347,共3页
Chinese Journal of New Drugs
