摘要
目的:观察美洛昔康(meloxicam)经两种给药途径对大、小鼠的急性毒性反应,评价其安全性。方法:以小鼠和大鼠为对象,将美洛昔康按灌胃和腹腔注射两种给药方式进行急性毒性试验,用Bliss法测得LD50及95％置信限。结果:小鼠ig给药LD50:840．0(668．0～1057．0)mg·kg-1。小鼠ip给药LD50:143．9(111．7～185．5)mg·kg-1。大鼠ig给药LD50:219．9 (186．1～259．9)mg·kg-1。大鼠ip给药LD50:116．4(98．3～137．9)mg·kg-1。结论:美洛昔康属于低等毒性物质。
Objective： To observe the acute toxicity reaction of Meloxieam in rats and mice, and evaluate the safety of the drug. Method.. The drug was administered to the rats and mice by ig and ip during the acute toxicity test ,LD50 and 95% confidence limit of the drug were determined by Bliss＇ methods. Result： LD50 and 95 % confidence limit of the drug in mice by ig/ip were 840.0 mg·kg^-1 （668.0～1057.0 mg·kg^-1 ） and 143.9 mg·kg^-1 （ 111.7～185.5 mg·kg^-1 ） respectively. LD50 and 95 % confidence limit of the drug in rats by ig/ip were 219.9 mg·kg^-1 （ 186.1～259, 9 mg·kg^-1 ） and 116.4 mg·kg^-1 （98.3 ～137.9 mg·kg^-1 ） respectively. Conclusion： Meloxieam is a drug of low toxicity.
出处
《中国药师》
CAS
2006年第10期915-917,共3页
China Pharmacist
