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壮骨关节胶囊联合美洛昔康治疗早期膝骨关节炎的临床疗效

Clinical efficacy of Zhuangguguanjie capsule combined with meloxicam in the treatment of early knee osteoarthritis
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摘要 目的探讨壮骨关节胶囊联合美洛昔康治疗早期膝骨关节炎(KOA)的临床疗效。方法选取2020年1—6月本院收治的102例早期KOA患者作为研究对象,按照随机数字表法分为两组,每组51例。对照组给予美洛昔康治疗,观察组在对照组基础上联合壮骨关节胶囊治疗,比较两组临床疗效、西安大略和麦克马斯特大学关节炎指数(WOMAC)评分及不良反应发生率。结果观察组治疗总有效率为94.12%,高于对照组的80.39%,差异有统计学意义(P<0.05)。治疗前,两组WOMAC评分比较差异无统计学意义;治疗后,两组WOMAC评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为11.76%,对照组为9.80%,两组不良反应发生率比较差异无统计学意义。结论壮骨关节胶囊联合美洛昔康治疗早期KOA疗效确切,可改善患者膝关节功能,安全有效,值得临床推广应用。 Objective To investigate the clinical efficacy of Zhuangguguanjie capsule combined with meloxicam in the treatment of early knee osteoarthritis(KOA).Methods 102 patients with early KOA in our hospital from January to June 2020 were selected as the research subjects,and they were divided into two groups according to the random number table method,with 51 cases in each group.The control group were treated with meloxicam,and the observation group was treated with Zhuangguguanjie capsule on the basis of the control group,the efficacy,Western Ontario and McMaster Universities arthritis index(WOMAC)score and incidence of adverse reaction were compared between the two groups.Results The total effective rate in the observation group was 94.12%,which was higher than 80.39%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the WOMAC scores between the two groups;after treatment,the WOMAC scoresin the two groups were lower than those before treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 11.76%,and the control group was 9.80%,there was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Zhuangguguanjie capsule combined with meloxicam in the treatment of early KOA patients has positive effect,can improves knee joint function,is safe and effective,and is worthy of promotion and application.
作者 黄朝晖 刘继亮 钟志泉 HUANG Chaohui;LIU Jiliang;ZHONG Zhiquan(Department of Orthopedics and Traumatology,Ruijin Hospital of Traditional Chinese Medicine,Ruijin,Jiangxi,342500,China)
出处 《当代医学》 2022年第26期125-128,共4页 Contemporary Medicine
关键词 壮骨关节胶囊 美洛昔康 早期膝骨关节炎 骨关节炎指数 Zhuangguguanjie capsule Meloxicam Early knee osteoarthritis Osteoarthritis index
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