摘要
目的：探讨重庆地区男男性行为者（men who have sex with men,MSM）对暴露前药物预防（pre-exposure prophylaxis,PrEP）措施用于降低人类免疫缺陷病毒（human immunodeficiency virus,HIV）感染风险的接受意愿及其影响因素。方法：采用滚雪球抽样法招募了重庆地区448名MSM,采用调查员协助下的自填问卷方式对他们进行问卷调查,了解MSM艾滋病相关知识、态度、行为特征、艾滋病预防措施的知识、态度、使用意愿、对PrEP知晓情况及接受意愿。采用单因素和多因素的Logistic回归。结果：PrEP在保证药物安全有效的前提下,重庆MSM人群的接受意愿可以达到76.2%左右。多因素Logistic回归分析结果表示：与MSM人群接受PrEP的意愿呈显著联系的因素有：月经济收入[OR：4.775,95%CI（1.274~17.895）,P=0.020 4;OR：1.945,95%CI（0.594~6.376）,P=0.271 8;OR：1.427,95%CI（0.357~5.698）,P=0.615 0]、对艾滋病感染者/病人的态度[OR：3.487,95%CI（0.759~16.021）,P=0.108 4;OR：4.646,95%CI（1.208~17.860）,P=0.025 4]、是否做过艾滋病病毒检测[OR：2.361,95%CI（1.118~4.986）,P=0.024 3]、是否认为应该在MSM人群中推广PrEP[OR：51.365,95%CI（5.184~508.960）,P=0.000 8;OR：8.985,95%CI（0.836~96.509）,P=0.069 9]、是否会建议您朋友采用PrEP[OR：30.882,95%CI（2.121~449.700）,P=0.012 1;OR：2.529,95%CI（0.167~38.315）,P=0.503 4]。结论：重庆地区MSM人群对PrEP接受意愿主要与对待艾滋病的态度和对待艾滋病预防措施的态度有关。提示应加强对MSM人群预防艾滋病的健康教育、扩大艾滋病咨询检测服务工作、加强MSM和PrEP供应商对PrEP的正确认识和宣传、通过网络途径促进MSM同伴教育和对PrEP的传播,以增加MSM人群对PrEP的接受意愿。
Objective：To investigate the acceptability of pre-exposure prophylaxis（PrEP） to prevent the transmission of human immunodeficiency virus（HIV） among men who have sex with men（MSM） in Chongqing.Methods：Totally 448 MSM were recruited by snowball sampling methods in Chongqing.Self-administered questionnaire survey was conducted among the recruited 448 MSM with assistant investigators collecting information on HIV-related knowledge,attitude and risk behaviors,HIV preventive measures-related knowledge,attitude and acceptability of and PrEP-related knowledge and acceptability.Univariate and multivariate Logistic regression were employed for statistical analysis.Results：The acceptability of PrEP among MSM in Chongqing reached 76.2% in the premise of drug safety and effectiveness.Results of multivariate Logistic regression analysis indicated that the factors significantly associated with acceptability of PrEP among MSM were：monthly income（OR：4.775,95%CI（1.274,17.895）,P=0.020 4;OR：1.945,95%CI（0.594,6.376）,P=0.271 8;OR：1.427,95%CI（0.357,5.698）,P=0.615 0）,attitudes towards HIV patients（OR：3.487,95%CI（0.759,16.021）,P=0.108 4;OR：4.646,95%CI（1.208,17.860）,P=0.025 4）,detection of HIV（OR：2.361,95%CI（1.118,4.986）,P=0.024 3）,PrEP promotion among MSM（OR：51.365,95% CI（5.184,508.960）,P = 0.000 8;OR：8.985,95%CI（0.836,96.509）,P=0.069 9）,advising friends to use PrEP（OR：30.882,95%CI（2.121,449.700）,P= 0.012 1;OR：2.529,95%CI（0.167,38.315）,P=0.503 4）.Conclusions：Acceptability of PrEP among MSM in Chongqing is mainly related with attitudes towards AIDS and preventive measures for AIDS,indicating that education on HIV/AIDS prevention among MSM should be reinforced,AIDS consulting and HIV testing work should be expanded,PrEP should be further understood and propagandized among MSM and providers and peer education and propagation for PrEP among MSM via internet should be improved,thus acceptability towards PrEP could be possibly increased.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2013年第4期389-394,共6页
Journal of Chongqing Medical University
基金
国家科技重大专项资助项目(编号:2008ZX10001-016)
关键词
男男性行为者
人类免疫缺陷病毒
暴露前药物预防
接受意愿
men who have sex with men
human immunodeficiency virus
pre-exposure prophylaxis
acceptability
