摘要
目的探讨复方甘草酸苷辅助治疗艾滋病合并皮肤病的临床疗效。方法选取无锡市第五人民医院2013年6月至2015年6月的40例艾滋病合并皮肤病患者,随机分为对照组和观察组,每组20例。对照组给予单一的高效抗反转录病毒治疗(HAART),观察组在HAART的基础上给予复方甘草酸苷辅助治疗,比较两组的皮肤病治疗的有效率和对艾滋病T细胞亚群的影响。结果观察组在治疗荨麻疹、过敏性紫癜、皮肤瘙痒症、扁平苔癣、银屑病等方面的有效率明显高于对照组(P<0.05);观察组CD8+CD38+T细胞下降比对照组明显(P<0.05);治疗6个月后,观察组患者CD4+T淋巴细胞计数升高比对照组显著(P<0.05)。结论观察组治疗皮肤病效果明显比对照组好,艾滋病治疗效果较对照组明显,说明复方甘草酸苷辅助治疗艾滋病合并皮肤病方面疗效显著,值得临床推广。
Objective To study the clinical curative effect of adjunctive therapy of compound glycyrrhizin glucoside for AIDS patients merged with skin diseases.Methods 40 AIDS patients merged with skin diseases were selected from Wuxi fifth People’s hospital during June 2013 to June 2015,and divided into two groups with 20 cases in each.Patients in both groups were treated by highly active antiretroviral therapy（HAART）,and the patients in observation group received the therapy of compound glycyrrhizin glucoside.Then comparison was made between the two groups to the therapeutic effects and T cell subgroup of HIV.Results Observation group had a significantly higher effect in the treatment of urticaria,allergic purpura,itchy skin,lichen planus,and psoriasis than the control group（P〈0.05）.CD8＋CD38＋T cells of observation group decreased more obviously than those of the control group（P〈0.05）.After being treated for 6months,the patients in observation group got their CD4＋T cell count increased more significantly than those in the control group（P〈0.05）.Conclusion Curative effect of observation group was better than that of control group in the treatment of skin disease,as well as the treatment of AIDS.Compound glycyrrhizin glucoside has obvious therapeutic effect on the AIDS patients co-infected with skin diseases,and it is worthy of clinical popularization.
出处
《中国艾滋病性病》
CAS
北大核心
2016年第6期413-415,共3页
Chinese Journal of Aids & STD
关键词
复方甘草酸苷
艾滋病
皮肤病
Compound glycyrrhizin glucoside
HIV/AIDS
Skin disease
