摘要
利用大鼠研究脯氨酸被吸收后羟基化修饰对血液和尿液中羟脯氨酸含量的影响,在此基础上利用平均分子量分别为1 kDa、3 kDa和大于20 kDa的胶原蛋白肽考察了分子量范围对多肽吸收速率的影响。结果表明平均分子量为1 kDa和3 kDa的吸收速率高于平均分子量20 kDa的胶原蛋白肽,平均分子量1 kDa的多肽吸收速率高于平均分子量3kDa的多肽。实验借助胃炎大鼠模型考察了胃功能缺陷对不同分子量的多肽吸收速率的影响,证明了高分子量多肽由于吸收速率较低导致在血浆中Hyp浓度衰减速率较低,而低分子量多肽受胃消化过程影响较小。
The effect of hydroxylation of proline on the content of hydroxyproline in blood and urea was studied with rat. Then, the effect of molecular Weight range of peptide on the adsorption in rat were investigated by using peptide with mean MW of lkDa （ CP1 ）, 3kDa（ CP2）, and 20kDa （CP3）. The result indicated that the CP1 and CP2 showed higher adsorption rate than CP3, and CP1 showed higher adsorption rate than CP2. The experiments were repeated with rat model of gastritis. It was found CP3 showed less adsorption rate than CP1 and CP2 caused by the low digestion in stomach. However, the effect of low molecular weight peptides digestion in stom- ach on the adsorption in rat was not obvious.
出处
《生物学杂志》
CAS
CSCD
2013年第2期10-13,共4页
Journal of Biology
基金
国家863项目(2010AA023005)
北京市自然科学基金(7102108)
关键词
胶原蛋白肽
羟脯氨酸
分子量
吸收速率
collagen peptides
hypdoxyproline
molecular weight
adsorption rate
