摘要
目的:探讨孕期注射乙肝免疫球蛋白(hepatitis B immunoglobulin,HBIG)对HBV母婴传播的影响及婴儿对乙肝疫苗免疫应答情况。方法:以HBsAg阳性孕妇及其新生儿为研究对象,孕期注射乙肝免疫球蛋白的孕妇300例及新生儿为实验组,未使用者80例为对照组,比较两组新生儿宫内感染率及出生时和7个月抗体产生情况。结果:孕期注射HBIG组与未注射组新生儿宫内感染率分别为5.33%(16/300)和1.25%(1/80),差异无统计学意义(χ2=2.464,P>0.05);孕期注射HBIG组与未注射组新生儿出生时anti-HBs阳性率分别为10.33%(31/300)和1.25%(1/80),差异有统计学意义(χ2=6.757,P<0.05),7个月龄anti-HBs产生率为96.12%(124/129)和95.35%(41/43),差异无统计学意义(χ2=0.049,P>0.05);出生时anti-HBs阳性的新生儿25例,7个月复查均产生anti-HBs,而出生时anti-HBs阴性或弱阳性的147例婴儿,7个月复查有7例婴儿anti-HBs仍为阴性或弱阳性,但差异无统计学意义(χ2=0.321,P>0.05)。结论:孕期注射HBIG不能降低HBV宫内感染率,可提高新生儿出生时anti-HBs阳性率,但对7个月anti-HBs产生率无影响。
Objective: To explore the effect of injection of hepatitis B immunoglobulin (HBIG) during gestational period on mater- nal -infantile transmission of hepatitis B virus (HBV) and immune response of infants to HBV vaccine. Methods: The pregnant women with positive HBsAg and their neonates were selected as research objects, 300 pregnant women who were treated with injection of HBIG dur- ing gestational period and their neonates were selected as experimental group, and 80 pregnant women who didnl receive the treatment and their neonates were selected as control group ; the incidence rates of intrauterine infection of neonates and the productions of HBV antibodies at seven months after birth were compared between the two groups. Results: The incidence rates of intrauterine infection in experimental group and control group were 5.33% (16/300) and 1.25% (1/80), respectively, there was no statistically significant difference between the two groups (X2 = 2. 464, P 〉 0. 05 ) , The positive rates of HBsAb of neonates at birth in experimental group and control group were 10. 3% (31/300) and 1.25% ( 1/80), respectively, there was statistically significant difference between the two groups (X2 =6. 757, P 〈 0. 05) ; the production rates of HBsAb in experimental group and control group at seven months after birth were 96. 12% (124/129) and 95.35% (41/43), respectively, there was no statistically significant difference between the two groups (X2 =0, 049, P 〉0. 05) ; 25 neo- nates were found with positive HBsAb at birth and at seven months after birth; while among 147 neonates with negative or weak positive HB- sAb at birth, 7 neonates were found with negative or weak positive HBsAb at seven months after birth, but there was no statistically signifi- cant difference (X2 = 0. 321, P 〉 0. 05 ) . Conclusion: Injecting HBIG during gestational period can't reduce HBV intrauterine infection rate, while it can raise the positive rate of HBsAb at birth, but the method has n
出处
《中国妇幼保健》
CAS
北大核心
2013年第4期639-643,共5页
Maternal and Child Health Care of China