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外周血单个核细胞在乙肝病毒传播中的作用 被引量:2

Significance of hepatitis B virus infected mononuclear cells in peripheral blood
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摘要 在急性乙肝和慢性乙肝患者的外周血单个核细胞都有不同程度的乙型肝炎病毒感染。外周血单个核细胞不但可以从外周血摄取乙型肝炎病毒 ,而且乙型肝炎病毒可在其内复制、转录、翻译并能释放病毒颗粒 ,具有一定的感染性。乙型肝炎病毒感染外周血单个核细胞可逃避免疫反应 ,导致病情的隐匿化。当外周血单个核细胞所处的外环境改变时 ,可导致其再次激活 ,引起肝移植术后乙肝复发。 Whatever chronic or acute infection of HBV, peripheral blood mononuclear cells (PBMC) are infected by HBV in some extent. PBMC can take in HBV. In it, HBV replicates, transcripts, translates and releases some viral particles, indicating that the infected PBMC have capacity to infect other cells and tissues. HBV infection of PBMC might lead to selection of HBV variants which would escape from immunity of the body. What's more, it would result in latent hepatitis B virus infection. HBV in PBMC can be reactivated when the endo-environments changes, resulting in HBV reinfection after orthotropic liver transplantation and transmission of HBV by transfusion, and mother-to-infant transmission.
出处 《国外医学(妇幼保健分册)》 2004年第5期296-297,i005,共3页 Foreign Medical Sciences (Section of Maternal and Child Health)
关键词 肝炎病毒 乙型 外周血单个核细胞 母婴传播 hepatitis B virus peripheral blood mononuclear cell mother-to-infant transmission
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