摘要
目的通过分析乙型肝炎病毒携带(简称乙肝)产妇乙肝血清标志物与血清、乳汁及脐血中HBV-DNA阳性率的关系以及乙肝孕妇血清HBV-DNA含量与其乳汁,脐血中HBV-DNA含量相关性,探讨乙肝孕妇宫内感染的可能性及母乳喂养的安全性问题并指导母乳喂养。方法选择在我院住院分娩乙肝病毒携带产妇100例。测定其血清标志物,同时分别检测其孕晚期血清,产时脐血及产后乳汁中HBV-DNA含量。结果乙肝产妇血清中各种模式与其血清的HBV-DNA阳性率比较,其中HBsAg、HBeAg、HBcAb模式阳性率最高,HBsAg、HBcAb模式阳性率最低。血清HBeAg阳性产妇血清中HBV-DNA阳性率明显高于HBeAg阴性产妇,两者比较有显著差异(P<0.01)。乙肝产妇血清HBeAg阳性其乳汁、脐血中HBV-DNA阳性率高,乙肝产妇血清HBeAg阴性其乳汁、脐血中HBV-DNA阳性率低。按血清标志物HBeAg是否阳性将乳汁、脐血中HBV-DNA阳性率分别分为HBeAg阳性组,HBeAg阴性组,分别配对比较差异显著(P<0.01)有统计学意义。血清中HBV-DNA含量与乙肝产妇乳汁、脐血中HBV-DNA含量呈正相关,分别为(r=0.593,P<0.05)、(r=0.553,P<0.05)。结论:HBV-DNA定量检测能准确反映乙肝病毒在体内复制情况与宿主传染性,可以作为检测乙肝母婴传播指标。乙肝产妇定量检测血清、乳汁、脐血中HBV-DNA及其乙肝标志物有利于阻断乙肝传播,确定哺乳方式,指导母乳喂养,从而降低乙肝新生儿感染率。
Objective Through analysis of the relationship between the hepatitis B serum marker of HBV-infectious pregnant women and the HBV-DNA positive rate in serum, milk and cord blood. And the correlationship of HBV-DNA content between HBV-infectious pregnant woman serum, milk and cord blood. Then, research into the possibility of intranterine infection and whether the breast feeding is safe. Give some instructions on breast-feeding. Methods Choose 100 HBV-infectious pregnant women in our hospital. And have hepatitis B serum markers detected, at the same time detecting the HBV-DNA content of serum in the third trimester of pregnancy, Cord blood of intrapartum, the milk after child -birth respectively. Results Compare hepatitis B serum markers of HBV-infectious pregnant woman with HBV-DNA positive rate of serum. The positive rate of HBsAg, HBeAg HBcAb is the highest. The positive rate of HBsAg, HBcAb is the lowest. The HBV-DNA positive rate of HBeAg-positive pregnancy women is obviously higher than HBeAg-negative. There are significant differences. (p<0.01).If HBeAg of HBV-infectious pregnancy women is positive, the HBV-DNA positive rate of milk and the cord blood is high. If it is negative , the rate is low. According to serum marker HBeAg is positive or negative, we divide the HBV-DNA positive ratio of milk and cord blood into HBeAg-positive group and HBeAg-negative group. Paired comparision on separate has significant differences. It has statistical significance. The HBV-DNA content of serum has direct relation with the HBV-DNA content of milk and cord blood. It is (r=0.593,p<0.05), (r=0.553,p<0.05). Conclusion The quantitative measurement of HBV-DNA can accurately illustrate the situation of HBV duplicate in vivo and infection of the host, which can be the index as detecting transmission from mother to infant. If HBV-infectious pregnant woman is detected about the HBV-DNA content of serum, milk, cord blood, and the hepatitis B serum markers mode, It is helpful in interruption HBV transmission, deciding the mode of br
出处
《医学检验与临床》
2008年第5期55-57,共3页
Medical Laboratory Science and Clinics
关键词
母婴传播
HBV-DNA
母乳喂养
乳汁
脐血
Transmission from mother to infant
Hepatitis B markers
HBV-DNA
Breast-feeding
Milk
Cord blood
