摘要
目的分析孕妇乙型肝炎病毒(HBV)感染模式及感染相关状况与新生儿宫内感染的临床关系,为治疗孕妇HBV感染提供参考依据。方法选取2013年10月-2014年12月医院HBV感染的40例孕妇患者为研究对象,采取ELISA检测孕妇以及新生儿的乙型肝炎血清标志物(HBVM),使用PCR检测外周血单核细胞(PBMC)内HBV-DNA的相关指标。结果 40例孕妇HBV患者的总感染率为10.23%,孕妇HBV感染模式中约有12种,孕妇HBV阳性感染率为10.11%;6种模式中以小三阳模式最为多见,占总比例的97.88%,小三阳的孕妇HBV检出率为20.58%,大三阳的孕妇HBV检出率为96.35%,两组数据比较差异有统计学意义(P<0.05)。结论 40例研究对象中存在一定程度HBV感染,以小三阳模式最为常见。
OBJECTIVE To analyze the relationship between the hepatitis B virus（HBV）infection mode of pregnant women and the intrauterine infections in neonates so as to provide guidance for clinical treatment of the pregnant women with HBV infections.METHODS A total of 40 pregnant women with HBV infections who were treated in the hospital from Oct 2013 to Dec 2014 were recruited as the study objects,then the hepatitis B serological markers of the pregnant women and neonates were detected by using ELISA,and the related indicators of HBV-DNA in peripheral blood monouclear cells（PBMC）were detected by means of PCR.RESULTS The total incidence of HBV infection was 10.23%in the 40 pregnant women,there were about 12 kinds of HBV infection modes,and the positive rate of HBV infections was 10.11%.The′small three positive mode′was most common among the 6modes,accounting for 97.88%.The detection rate of HBV was 20.58%in the pregnant women with the′small three positive mode′,while the detection rate of HBV was 96.35%in the pregnant women with′big three positive mode′,and there was significant difference between the two groups of data（P〈0.05）.CONCLUSION The 40 study objects have certain HBV infections,and the′small three positive mode′is the most common.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第13期3066-3068,共3页
Chinese Journal of Nosocomiology
基金
湖北省卫生厅科技基金资助项目(HW-2010B-1013)
关键词
孕妇
乙型肝炎病毒
宫内感染
乙型肝炎血清标志物
外周血单核细胞
Pregnant woman
Hepatitis B virus
Intrauterine infection
Hepatitis B serological marker
Peripheral blood monouclear cell
