摘要
巨噬细胞是天然免疫系统的主要成员，是肿瘤微环境中重要的免疫细胞，能促进肿瘤的发生、发展。根据巨噬细胞的不同特征，可分为M1型和M2型。通过对乳腺癌、肺癌、妇科恶性肿瘤等研究发现，肿瘤相关巨噬细胞具有类似于M2型巨噬细胞的表型和功能，可以促进瘤组织内新生血管及淋巴管的形成，进而促进肿瘤的发生、发展，是预后不良的重要指标。巨噬细胞在肿瘤微环境中的表型和功能受多重因素的影响，如TGF、IL-10和PGE-2等，并能促进其转化。本文对巨噬细胞在肿瘤发生、发展中的作用及机制进行综述。
Macrophages, as an important member of innate immune system, constitute a major component of the microenvironment of tumours, and play an important role in the occurrence and development of tumor. According to particular phenotypes and functions, macrophages can be divided into M1 macrophages and M2 macrophages. In the research of breast cancer, lung cancer, gynecological malignancies, researchers have found that tumor-associated macrophage has the similar phenotype and function of M2 macrophages. Tumor-associated macrophage can promote the formation of new blood vessels and lymphatic vessels in tumor tissue, thus contributing to the occurrence and development of tumor. The relation between tumor-associated macrophage and poor prognosis was also be found. The tumor microenvironment can affec, t the phenotype and function of maerophages, such as TGF, IL-10 and PGE-2. This paper reviewed the role and mechanism of macrophages in the tumorigenesis.
出处
《国际外科学杂志》
2012年第12期839-842,共4页
International Journal of Surgery
基金
陕西省科技攻关项目（No.2011K13-03-08）
关键词
巨噬细胞
肿瘤
免疫
Macrophages
Neoplasms
hnmunity
