摘要
DNA双链断裂是真核生物最严重的DNA损伤形式。如果断裂的DNA双链无法及时修复,将可能导致细胞死亡。非同源末端连接途径在真核生物DSBs修复中起重要作用。综述了真核生物NHEJ途径中核心蛋白质Ku、DNA-PKcs、DNA连接酶IV、XRCC4、ARTEMIS和XIF等因子的结构和功能,并简要介绍了NHEJ修复途径的分子机制,其中涉及到DSBs位点蛋白复合体组装的两种模型。
DNA double strand breaks are the most harmful form of DNA damage in eukaryotic Cells. If not repaired in time,the breakages can result in cell death. Non-homologous end joining pathway plays an important role in eukaryotic DSBs repair. In this review, an overview of the structure and functions of NHEJ core factors, encompassing Ku, DNA-PKes, DNA ligase IV, XRCC4, ARTEMIS and XIF was provided. Also,a brief introduction to the molecular mechanism of NHEJ,involving two models regarding protein complex assembly at DSBs was given.
出处
《生物技术通报》
CAS
CSCD
北大核心
2009年第10期55-59,共5页
Biotechnology Bulletin
基金
国家自然科学基金项目(30670035)
北京市教委科技发展面上项目(KM200510028011)
