摘要
复发性自然流产(RSA)是多基因遗传变异和环境等多重因素共同作用的结果。成功的妊娠依赖于Th1和Th2的免疫平衡,白细胞介素6(IL-6)作为Th2型细胞因子,是维持Th1/Th2平衡的重要因素之一。IL-6基因启动子区-174G/A和-572G/C与IL-6表达水平相关,从而影响流产的发生。该文就IL-6启动子区域基因多态性与RSA的相关性予以综述。
Recurrent spontaneous abortion is the result of multiple genes and multiple environment factors. Successful pregnancy depends on Th1 and Th2 immune balance,and as a Th2 type cytokine,IL-6 is one of the important factors for maintaining Th1/Th2 balance. Studies show that the IL-6 promoter region - 174G/C and -572C/G arc associated with IL-6 expression level, which then induces abortion. Here is to make a review of the association between polymorphism of IL-6 promoter region and recurrent spontaneous abortion.
出处
《医学综述》
2014年第21期3862-3865,共4页
Medical Recapitulate
基金
云南省科技厅-昆明医学院联合专项(2011FB234)
云南省科技厅应用基础研究自筹经费项目(2010ZC201)
