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MicroRNA在糖尿病及其并发症中的研究进展 被引量：7

Current research progress in microRNA in diabetes mellitus and diabetes-associated complications
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摘要 糖尿病是一种多重因素包括遗传、环境和社会心理等相互作用导致的慢性代谢性疾病。MicroRNA(miRNA)对葡萄糖的摄取和平衡有重要的作用,与IR的发展也密切相关,对于糖尿病的预防和治疗研究有重要意义。 Diabetes mellitus is a chronic metabolic disease caused by various factors, such as genetic, environmental, and psychosocial factors, etc. The finding is that microRNA （miRNA） plays an important role in glucose uptake and balance and is also involved in the development of insulin resistance （IR）. MicroRNA is of great significance in prevention and treatment of DM.
作者 朱玲玲 鲁一兵
机构地区 南京医科大学第二附属医院内分泌科
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2013年第6期568-570,共3页 Chinese Journal of Diabetes
关键词 MICRORNA 糖尿病 糖尿病并发症 胰岛素 MicroRNA （miRNA） Diabetes mellitus Diabetic complications Insulin
分类号 R587.2 [医药卫生—内分泌]
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参考文献13

  • 1Danaei G, Finucane MM, Lu Y, et al. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2. 7 mil- [ion participants. The Lancet, 2011, 378:31-40. 被引量：1
  • 2Gauthier BR, Wollheim CB. MicroRNAs: 'ribo-regulators' of glucose homeostasis. Nat Med, 2006, 12 : 36-38. 被引量：1
  • 3Winter J, Jung S, Keller S, et al. Many roads to maturity: mi- croRNA biogenesis pathways and their regulation. Nat Cell Bi- ol, 2009, 11:228-234. 被引量：1
  • 4Baroukh N, Ravier MA, Loder MK, et al. MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancre- atic beta-cell lines. J Biol Cbem, 2007, 282:19575-19588. 被引量：1
  • 5Plaisance V, Abderrahmani A, Perret-Menoud V, et al. Mi- croRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells. J Biol Chern, 2006, 281 : 26932-26942. 被引量：1
  • 6He A, Zhu L, Gupta N, et al. Overexpression of micro ribonu- cleic acid 29, highly up-regulated in diabetic rats, leads to insu- lin resistance in 3T3-L1 adipocytes Mol Endocfinol, 2007, 21: 2785-2794. 被引量：1
  • 7Jordan SD, Kriiger M, Willmes DM, et al. Obesity-indnced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nat Cell Biol, 2011, 13: 434-446. 被引量：1
  • 8Kato M, Zhang J, Wang M, et al. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors: Proc Natl Acad Sci U S A, 2007, 104:3432-3437. 被引量：1
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中国糖尿病杂志
2013年 第6期

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