摘要
慢性阻塞性肺疾病（COPD）是一种严重影响人类健康的慢性病，由于早期诊断困难，临床迫切需要寻找某种生物标记物，作为COPD诊断、严重程度评价及预后的评估指标。肺表面活性蛋白-D（SP-D）、Clara细胞分泌蛋白（CC16）作为潜在的COPD的新型特异性生物标记物，主要由肺产生，其生物学特性在COPD的发病机制中起作用。肺及血清中SP-D、CC16水平与COPD的发生、发展密切相关。本文对SPD、CC16的结构、生理功能及其与COPD的关系进行综述。
Chronic obstructive pulmonary disease （COPD）is a chronic disease which affects the human health seriously. Due to the difficulty of diagnose early,one biomarker is urgent needed to diagnose and evaluate the disease. Surfactant Protein D （SP-D） and Clara Ceil Secretory Protein （CC16） produced mainly by lung are potential new biomarkers of COPD. Their characters play an important role in the mechanism for COPD. The level of SP-D,CC16 in serum and lung is closely related to the occurrence and development of COPD. The review is about the structure, function and relationship between COPD.
出处
《国际呼吸杂志》
2012年第19期1489-1492,共4页
International Journal of Respiration
