摘要
肾功能损伤是多发性骨髓瘤(MM)患者最常见的严重并发症之一,是导致MM患者易发生感染以及早期死亡的主要原因。本周氏蛋白(BJP)的催化活性是其致肾损伤的重要因素并影响MM患者病情进展。研究指出,BJP具有水解肽及裂解DNA的催化活性,并在体外细胞实验中导致猪肾小管上皮细胞(LLC-PK1)凋亡。将BJP经过丝氨酸蛋白酶抑制剂DFP处理后,其催化活性丧失的同时对细胞诱导凋亡的作用也随之消失。因此,深入研究阐明BJP的致病机制有助于了解MM患者肾损伤的发生,并可能对治疗MM肾损伤患者提供一种新的方法。本文就近年对BJP催化活性的基础研究及其进展作一综述。
Renal impairment is one of frequent and serious complications in patients with multiple myeloma（MM） and is associated with a higher incidence of infections and early death rate.The catalytic activity of Bence Jones proteins（BJP） affects the clinical processes of patients with MM,and can lead to renal impairment.Scientists point out that BJP have peptidolytic and nucleolytic activity,which can lead porcine kidney proximal tubule（LLC-PK1）to apoptosis in vitro experiments.By treating the cytotoxic BJP with serine protease inhibitor（DFP）,BJP lost not only their catalytic activity,but also the cytotoxic effects.Therefore,further research on BJP will helpful to understand the pathogenesis of renal impairment in MM patients and may provide a new idea and measure for the treatment of MM with renal impairment.This article reviews the basic research and progress on the catalytic activity of BJP.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2012年第3期796-800,共5页
Journal of Experimental Hematology
基金
南京军区医学科技创新课题(编号:10MA096)
关键词
本周氏蛋白
多发性骨髓瘤
肾损伤
催化活性
Bence Jones protein
multiple myeloma
renal impairment
catalytic activity
