摘要
目的探讨血清胱抑素C(Cys-C)、尿视黄醇结合蛋白(RBP)对多发性骨髓瘤(MM)患者早期肾损伤的诊断价值。方法根据肾小球滤过率估计值(eGFR)将MM患者分为两组:A组为肾功能正常组(eGFR≥90mL/min)78例;B组为肾功能损伤组(eGFR<90mL/min)40例。130例健康体检者作为对照组。检测并比较各组血清Cys-C、尿RBP、血清尿素氮(UN)、血清肌酐(Cr)水平。结果 A组MM患者Cys-C和RBP水平与对照组比较,差异有统计学意义(P<0.01),B组Cys-C、Cr、UN、尿RBP水平均显著高于对照组(P<0.01)。Cys-C和尿RBP联合检测的阳性率为57.69%,明显高于单项检测(P<0.05)。结论 CysC和RBP比传统指标能更有效地诊断MM患者早期肾损伤,联合检测具有重要价值。
Objective To discuss the diagnostic value of serum cystatin-C（Cys-C）and urinary retinol binding protein（RBP）for the early renal impairment in multiple myeloma（MM）patients.Methods According to estimated glomerular filtration rate（eGFR）,the MM patients were divided into two groups：the normal renal function group（eGFR≥90mL/min,n=78）marked group A,the renal impairment group（eGFR90mL/min,n=40）marked group B.130 healthy subjects were selected as control group.The concentrations of serum Cys-C,urinary RBP,serum creatinine（Cr）and serum urea nitrogen（UN）were measured and compared.Results The levels of Cys-C and RBP in group A were significantly higher than those in the control group（P〈0.01）.There were significant difference of the levels of Cys-C,Cr,UN and RBP levels between group B and control group（P〈0.01）.The sensitivity of the combined detection of Cys-C and RBP was 57.69%,significantly higher than single index test（P〈0.05）.Conclusion Compared with traditional biomarkers,Cys-C and RBP are more sensitive and effective indexes for the diagnosis of early renal impairment in the patients with MM,and jointed detection of the two biomarkers has important value.
出处
《国际检验医学杂志》
CAS
2014年第21期2899-2900,共2页
International Journal of Laboratory Medicine
