摘要
目的:探讨胱抑素C联合尿视黄醇结合蛋白(RBP)检测对2型糖尿病患者早期肾损伤的诊断意义。方法:收集170例糖尿病患者及75例健康对照的外周血及尿液标本,采用免疫比浊法检测血清胱抑素C及尿液RBP的含量。结果:与正常对照组相比,糖尿病患者血清胱抑素C及尿RBP含量均明显升高,差异具有统计学意义(P<0.01);且糖尿病肾病患者血清胱抑素C及尿RBP含量明显高于单纯糖尿病患者(P<0.01)。单纯糖尿病患者胱抑素C阳性率为21.79%,尿RBP阳性率为32.05%,联合检测阳性率为46.15%;糖尿病肾病患者胱抑素C阳性率为阳性率为89.13%,尿RBP阳性率为91.30%,联合检测阳性率为97.83%。结论:血清胱抑素C及尿RBP均是检测糖尿病患者早期肾损伤的灵敏指标,联合检测胱抑素C和尿RBP能明显提高早期肾损伤的诊断敏感性。
Objective： To investigate the value of combined detection of cystatin c （Cyc-C） and retinol binding protein （RBP） in diagnosis of early renal injury of diabetes patients. Methods.. A total of 170 patients with diabetes mellitus and 75 healthy controls were enrolled in this study. The blood and urine samples were collected and immunoturbidimetricassays were used to detect serum Cyc-C and urinary RBP. Results： The serum level of Cyc-C and urinary RBP were both significantly higher in diabetes patients （all P〈0.01）, comparing to healthy controls. What＇s more, serum Cyc-C and RBP were both signifi- cantly higher in patients with diabetic nephropathy than patients with simple diabetes （all P〈0.01）. The positive rates of Cyc- C and RBP in patients with simple diabetes were 21. 79% and 32.05%, respectively; while the positive rate of combined detec- tion was 46.15%. The positive rates of Cyc-C and RBP in patients with diabetic nephropathy were 89.13% and 91.30%, respectively; while the positive rate of combined detectiong was 97.83%. Conclusions.- Serum Cyc-C and urinary RBP are sensi- tive markers for early renal injury of diabetes patients, and combined detection of these two markers can significantly up-regu- late the positive rate of detection of early renal injury in diabetes patients.
出处
《海南医学院学报》
CAS
2015年第2期203-205,共3页
Journal of Hainan Medical University
基金
四川省技术创新资助项目(2013CD00421)~~
