摘要
目的分析术前临床N0(cN0)期喉癌患者的临床病理特点与淋巴结转移及生存率的关系,探讨影响cN0期喉癌淋巴结转移及预后的相关因素,有效选择手术方式。方法应用回顾性调查研究方法,对1995年5月至2006年5月治疗的cN0期喉癌病例进行临床随访、病历资料分析。全组喉癌患者中临床cN0期患者157例,其中行淋巴结清扫可判断术后淋巴结转移与否的有118例,术后病理阳性41例。结果有9例失访。早期(Ⅰ、Ⅱ期)cN0期患者生存率高于中晚期(Ⅲ、Ⅳ期)患者,差异有统计学意义(P<0.01)。非声门型cN0期喉癌患者(包括声门上型和声门下型)生存率低于声门型喉癌,差异具有统计学意义(P<0.01)。肿瘤部位、病理组织学分级(pTNM)、T分期与cN0期喉癌淋巴结的转移有关(P<0.05)。结论肿瘤原发部位、pTNM、T分期与cN0期喉癌发生淋巴结转移及预后有关,对cN0期患者进行手术方式选择,预后评估具有重要意义。
Objective To analyze the relationship between clinic-pathological characteristics and prognosis of cN0 laryngeal carcinoma cases,explore the factors of impacting lymph metastases and prognosis in order to select the optimum procedures for cN0 laryngeal carcinoma cases.Methods A retrospective analysis of long-term following up and clinic-pathological materials were made on patients with cN0 laryngeal carcinoma underwent surgery during 1995.5-2006.5.Results There were only 9 missing cases among 118 cN0 laryngeal carcinoma cases.Lymph node metastases were confirmed in 41 cases post-operation.Statistical differences were noted between survival rate of earlv（Ⅰ,Ⅱstage）and advanced（Ⅲ,Ⅳstage）disease（P〈0.01）and between glottic and non-glottic cN0 carcinoma（P〈0.01）.The survival rate among those with lymph node metastasis was significantly different from those without lymph node metastasis （P〈0.01）.There were relationship between lymph node metastases and position of tumor,T stage,pTNM for cN0 cases.Conclusions The prognosis factors of cN0 laryngeal carcinoma were tumor stage,subsite and lymph node metastases.The factors are important for cN0 cases to select appropriate surgery fashions and assess the prognosis.
出处
《中华临床医师杂志（电子版）》
CAS
2010年第10期34-37,共4页
Chinese Journal of Clinicians(Electronic Edition)
关键词
喉肿瘤
淋巴结
颈淋巴结清扫术
存活率
Laryngeal neoplasms； Lymph nodes； Neck dissection； Survival rate；
