摘要
目的:检测原发性小肠恶性肿瘤中硫氧还蛋白-1(TRX-1)和转录活化因子-3(STAT-3)的表达和临床病理特征,并探讨二者之间的相关性.方法:用免疫组织化学法分别检测原发性小肠恶性肿瘤58例和癌旁正常小肠黏膜20例中TRX-1和STAT-3的表达.用半定量方法对免疫组织化学染色做评分,结合临床和病理数据进行分析.结果:TRX-1和STAT-3在原发性小肠恶性肿瘤中过度表达.他们较癌旁正常组织的表达显著增高.二者表达与正常组织有统计学的差异,且与病理分化不同有关(P<0.05或0.01).他们在中低分化肿瘤比高分化者表达增强;也同淋巴结转移和TNM分级密切相关(P<0.05或0.01).TRX-1和STAT-3在原发性小肠恶性肿瘤中的表达呈正相关(r=0.881,P<0.01).结论:Trx-1和STAT-3在原发性小肠恶性肿瘤组织中的过度表达并与其发生发展有关,二者单独或共同相互作用,可能参与了小肠恶性肿瘤恶化的调控.
AIM：To detect the expression of thioredoxin-1（TRX-1） and signal transducer and activator of transcription 3（STAT-3） and to analyze their relation to clinicopathological features in primary malignant tumors of the small intestine.METHODS：The expression of TRX-1 and STAT-3 in primary malignant tumors of the small intestine and matched tumor-adjacent normal tissue was detected by immunohistochemistry.The relationship between TRX-1 and STAT-3 expression and clinicopathological features in primary malignant tumors of the small intestine was then analyzed.RESULTS：Overexpression of TRX-1 and STAT-3 was detected in primary malignant tumors of the small intestine.The positive rates of TRX-1 and STAT-3 expression were significantly higher in tumor tissue than in tumor-adjacent normal tissue（both P 0.01）.The intensity of TRX-1 and STAT-3 expression was significantly higher in moderately and poorly differentiated tumor tissue than in well differentiated tumor tissue（P 0.05 or 0.01）.Increased expression of TRX-1 and STAT-3 is significantly correlated with lymph node metastasis and TNM stage（P 0.05 or 0.01）.There is a positive correlation between the expression of TRX-1 and STAT-3 in malignant tumors of the small intestine（r = 0.881,P 0.01）.CONCLUSION：TRX-1 and STAT-3 are overexpressed in primary malignant tumors of the small intestine,indicating that high expression of TRX-1 and STAT-3 may be involved in the genesis,development and progression of the disease.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第22期2327-2332,共6页
World Chinese Journal of Digestology
基金
广西壮族自治区卫生厅科研基金资助项目
No.Z2009194~~
关键词
小肠
恶性肿瘤
硫氧还蛋白-1
转录活化因子-3
表达
Small intestine
Malignant tumor
Thioredoxin-1
Signal transducer and activator of transcription 3
Expression
