摘要
目的探讨CD44v6在肝癌组织中的表达及其与肝癌患者预后的关系。方法应用流式细胞术定量检测新鲜肝癌组织中CD44v6的表达量,并与正常肝组织进行比较。分析CD44v6表达与肝癌患者预后的关系。结果肝癌组织CD44v6蛋白表达率为91.9%(34/37),显著高于正常肝组织的18.8%(3/16),差异有统计学意义(P<0.05)。肿瘤的浸润程度、分化程度不同,CD44v6蛋白表达量间差异有统计学意义(P<0.05);发生淋巴结转移的肝癌患者,CD44v6蛋白表达量(10.56±0.21)与无淋巴结转移患者的表达量(4.34±0.19)比较,差异有统计学意义(P<0.05)。结论CD44v6是评价肝癌预后的一个可靠指标,CD44v6高表达提示肝癌患者预后不良。
Objective To study the expressions of CD44v6 proteins in hepatoma and its relationship with the patients＇ prognosis.Methods The expressions of CD44v6 protein were detected by flow cytometry,the expression of CD44v6 and significant hepatoma prognostic factor was analyzed by multivariate Cox proportional hazards regression model.Results Most of hepatoma （34/37,91.9%） were expressed high level of CD44v6 protein,its level was higher than normal liver tissues（3/16,18.7%）,and its expression was tightly associated with tumor invasion,lymph node metastasis and Dukes stage by analysis of multivariate Cox proportional hazard model.Conclusion CD44v6 expression was evaluated a reliable indicator of poor prognosis for hepatoma,it was a target for hepatoma therapy.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第8期893-894,共2页
Chinese General Practice
