摘要
目的比较HBV相关原发性肝癌(hepatitis B virus-related primary hepatic carcinomas,HBV-PHC)患者与HCV相关原发性肝癌(hepatitis C virus-related primary hepatic carcinomas,HCV-PHC)患者的临床特征及生存期。方法回顾分析2002年1月-2006年6月河北医科大学第四医院收治的原发性肝癌患者312例,其中HBV-PHC患者184例,HCV-PHC患者51例,HBV和HCV相关原发性肝癌(hepatitis B plus hepatitis C-relatedprimary hepatic carcinomas,HBV+HCV-PHC)患者32例,非HBV非HCV相关原发性肝癌(non-hepatitis B nonhepatitis C-related primary hepatic carcinomas,NBNC-PHC)患者45例。对以上4组患者临床资料及生存期进行比较。生存曲线用Kaplan-Meier法,组间不同生存率比较用log-rank检验。结果与HBV-PHC患者相比,HCV-PHC患者的年龄大,男:女比率低,甲胎蛋白水平低,肿瘤较小,生存期较长,差异均有统计学意义。与HBV-PHC患者比较,HBV+HCV-PHC患者与NBNC-PHC患者年龄大,男:女比率低,生存期短,差异有统计学意义。结论 HCV-PHC患者具有较好的预后。
Objective To compare the clinical features and survival in patients with Hepatitis B virus-related primary hepatic carcinomas(HBV-PHC)and hepatitis C virus-related primary hepatic carcinomas(HCV-PHC).Methods The data of 312 hepatocellular carcinoma patients treated from January 2002 to June 2006 in the forth hospital of Hebei Medical University were retrospectively analyzed,include,184 patients with HCV-PHC,51 patients with HCV-PHC, 32 patients with coinfection of HBV and HCV primary hepatic carcinomas,45 patients with nonhepatitis B non-hepatitis C-related primary hepatic carcinomas.The clinical features and survival were compared in this study.The outcome of different groups were compared by using the Kaplan-Meier method and the differences in the survival rates between the groups were compared by the log-rank test.Results Compared with HBV-PHC patients,HCV-PHC patients were older,had a lower male/femal ratio,lower serum α-fetoprotein level,smaller tumor size and longer survival,there were very significant differences of all above between the two groups.Compared with HBV-PHC patients,HBV+HCV-PHC patients and NBNC-PHC patients were older,had a lower male/female ratio and shorter survival,there were very significant differentes of all above among the groups.Conclusion Compared with the patients with HBV-PHC,the patients with HCV-PHC have better overall survival.
出处
《河北医科大学学报》
CAS
2009年第10期992-996,共5页
Journal of Hebei Medical University
基金
河北省卫生厅重点医学项目(07108)
关键词
肝肿瘤
肝炎病毒
乙型
肝炎病毒
丙型
liver neoplasms
hepatitis B virus
hepatitis C virus
