摘要
目的在不同实验条件下制备多孔PLGA/脱细胞软骨基质支架,分析其结构与性能及作为软骨组织工程支架材料的可行性。方法将PLGA与猪脱细胞软骨基质按不同比例混合,在三种实验温度下,应用冷冻干燥法制备生物多孔复合物支架,并对各支架材料孔径、孔隙率、亲水性、生物力学强度和降解率进行研究。结果多孔PLGA/脱细胞软骨基质支架平均孔径为100～300μm,脱细胞软骨基质在PLGA三维结构中均匀分布,其结构和性能均符合软骨组织工程支架材料的要求。结论PLGA/脱细胞软骨基质支架可用于软骨组织工程研究。
Objective A novel biodegradable poly lactic-glycolic acid（PLGA）/ acellular cartilage matrix network compound was prepared by freeze drying method, which was investigated as a three-dimensional scaffold for cartilage tissue engineering. Methods The new porous compounds were fabricated under three different temperatures and the variable compositions of the original mixtures to control the structures and properties of the scaffolds,and each of which was analyzed of their pore sizes,porosity,hydrophilicity, biomechanical strength and degradability. Results The PLGA/acellular cartilage matrix compound could be made with regular microstructure,the pore size of which ranged from 100 to 300pm,and the acellular cartilage matrix was dispersed in the threedimensional structure of the eompound homogeneously. All the characteristics that referred above have been basically conformed to the requirement of a scaffold for cartilage tissue engineering. Conclusion The novel three dimensional PLGA/aeellular cartilage matrix compound is likely to be applied in the cartilage tissue engineering.
出处
《中国现代医生》
2009年第16期30-32,共3页
China Modern Doctor
关键词
聚乳酸羟基乙酸
托细胞软骨基质
组织工程
Poly lactic-glyeolic acid（PLGA）
Aeellular cartilage matrix
Tissue engineering
