摘要
目的探讨Ki-67、p53蛋白在乳腺癌及癌旁组织中的表达及两者之间的关系和临床意义。方法应用免疫组化S-P法检测80例乳腺癌组织及其癌旁的正常乳腺组织中Ki-67、p53蛋白的表达,分析其与临床病理因素的关系及两者的相关性。结果80例乳腺癌组织中Ki-67蛋白阳性表达率为63.8%,高于癌旁乳腺组织8.8%(P<0.05),其表达与患者年龄、肿瘤大小、ER、PR表达无关,与肿瘤的分期、腋窝淋巴结转移、C-erbB-2表达相关。乳腺癌组织p53蛋白阳性表达率为68.8%,高于癌旁乳腺组织11.3%((P<0.05),其表达与年龄、肿瘤大小、分期、ER、PR表达无关,与腋窝淋巴结转移、C-erbB-2表达相关。Ki-67蛋白与p53蛋白表达之间无关。结论Ki-67、p53蛋白可通过抑制细胞凋亡,对乳腺癌发生和发展起重要作用,是判断乳腺癌生物学行为、预测转移趋势有价值的参考指标。
Objective To investigate the expression of Ki-67 and p53 protein in breast cancer and paracarcinoma normal tissue and its clinical significance. Methods The expression of Ki-67 and p53 was examined by S-P immunohistochemistry in 80 samples of breast cancer and 60 samples of paracarcinoma normal tissue. The relationship of Ki-67 and p53 expression with clinicopathological parameters was analyzed. Results The positive expression rate of Ki-67 protein was 63. 8% in breast cancer and 8.8% in paracarcinoma normal tissues. The positive expression rate of p53 protein was 68.8% in breast cancer and 11.3% in paracarcinoma normal tissue. The expression of Ki-67 and p53 in breast cancer was not correlated with age ,tumor size,ER and PR expression;while correlated with stage,axillary lymph nodes metastasis and C-erbB-2 expression. There was no correlation between the expression rate of Ki-67 and p53 protein. Conclusion Ki-67 and p53 protein may play certain role in carcinogenesis and progress of breast cancer,which may be of value in predicting the biological behavior and metastasis of breast cancer.
出处
《实用肿瘤杂志》
CAS
北大核心
2009年第2期136-139,共4页
Journal of Practical Oncology
