摘要
目的探讨雌激素受体(ER)、孕激素受体(PR)、p53和C-erbB-2在乳腺癌组织中的表达及其临床意义。方法应用免疫组化方法检测经病理证实的51例乳腺癌组织的ER、PR、p53和C-erbB-2的表达。结果51例患者ER、PR、p53和C-erbB-2表达的阳性率分别为66.7%、58.8%、29.4%、72.6%。ER的表达在不同肿瘤大小、腋窝淋巴结有无转移组别中差异有显著性(P<0.05),而在年龄、分期组别中未见明显差异,PR、p53及C-erbB-2的表达与年龄、肿瘤大小、分期及淋巴结转移情况四组中均未见明显统计学意义。结论乳腺癌组织中ER、PR、p53和C-erbB-2均有较高表达,且ER表达与肿瘤大小、腋窝淋巴结转移密切有关。
Objective To study the expression of estrogen receptor （ER） ,prosgestogen receptor （PR） ,p53 and C-erbB-2 protein in breast cancer patients and their clinical significances. Method The expressions of ER,PR, p53 and C-erbB-2 were detected by immunohistochemical staining in 51 cases of breast cancer proved pathologically. Results The positive rates of ER,PR,I：63 and C-erbB-2 protein were 66.67% ,58.82% ,29.41% and 72.55% respectively in 51 cases with breast cancer. The expression of ER was found significant difference both in different tumor size groups and in groups with or without lymph node metastasis（ X^2 = 5. 1883, P 〈 0.05 ）, and No significant differences were found in different age groups and different stage groups. Expressions of PR,p53 and C-erbB-2 had no statistically significant in different age, tumor size, tumor stage and groups with or without lymph node metastasis. Conclusions Over expressions of ER,PR,p53 and C-erbB-2 are found in breast cancer tissue,the expression of ER correlates with tumor size and metastasis of lymph nodes.
出处
《中国临床保健杂志》
CAS
2006年第4期360-361,共2页
Chinese Journal of Clinical Healthcare
