摘要
目的:探讨乳腺癌组织中雌激素受体(ER),孕激素受体(PR),p53,C-erbB-2和增殖细胞核抗原(PCNA)在乳腺癌中的表达和与临床病理的关系.方法:应用免疫组化方法检测经病理证实的92例乳腺癌组织ER,PR,p53,C-erbB-2和PCNA的表达.结果:92例患者ER,PR,P53,C-erbB-2和PC-NA表达的阳性率分别为60.9%,58.8%,29.3%,71.7%和59.8%.ER的表达在不同肿瘤大小、腋窝淋巴结有无转移组别中差异有统计学意义(P<0.05);PR的表达与年龄、肿瘤大小、分期及淋巴结转移情况均无统计学意义(P>0.05);而C-erbB-2和PCNA在淋巴结有无转移之间表达差异具有统计学意义(P<0.05).结论:联合检测乳腺癌组织中ER,PR,P53,C-erbB-2和PCNA的表达对于判断乳腺癌预后和指导治疗具有临床参考价值.
AIM ： To study the expressions of estrogen receptor （ER）, progesterone reeeptor （PR）, P53, C-erbB-2 and proliferating eell nuelear antigen （PCNA） in breast eaneer tissues and their elinieal signifieanee. METHODS： The expressions of ER, PR, P53, C-erbB-2 and PCNA were deteeted by immunohisto- ehemistry in 92 eases of breast eaneer proved pathologieally. RESULTS： The positive rates of ER, PR, P53, C-erbB-2 and PCNA protein were 60. 9%, 58. 8%, 29. 3%, 71. 7% and 59.8% respeetively in breast eaneer tissues. The expression of ER was significantly different both in different tumor size groups and in groups with or without lymph node metastasis （ P 〈 0.05 ）. Expression of PR had no statistieally signifieant differenee among various age, tumor size, tumor stage groups and groups with or without lymph node metastasis. The expressions of C-erbB-2 and PCNA were positively eorrelated with lymph node metastases （ P 〈 0.05 ）. CONCLUSION： Combined deteetion of expressions of ER, PR, P53, C-erbB-2 and PCNA in primary breast eareinoma has praetieal value in the evaluation of prognosis and therapeutie effeets of breast eaneer patients.
出处
《第四军医大学学报》
北大核心
2008年第7期663-665,共3页
Journal of the Fourth Military Medical University
