摘要
目的研究NSCLC中S100A4蛋白的表达及其临床意义。方法采用免疫组化S-P法检测S100A4蛋白在58例非小细胞肺癌中的表达。结果58例NSCLC中32例S100A4蛋白表达阳性,阳性率为55.2%,S100A4蛋白的表达与非小细胞肺癌的患者年龄、肿瘤大小、淋巴结转移及预后有显著相关性,与组织学类型、性别、TNM分期无关。结论NSCLC中S100A4蛋白的表达与肿瘤的进展密切相关,是判断NSCLC生物学行为、预测转移趋势的有价值的指标。
Objective To study the expression of S100A4 protein and its clinical impact on non- small- cell lung cancer.Methods The expression of S100＆ protein was detected with immunohistochemistry SP mefhod in 58 non - small - cell lung cancers. Results The positive immtmohistochemical staining for S100A4 protein was observed in 32 of all patients, the positive ratio being 55.2%, the expression rate of S100A4 protein was associated with patients age,tumor size,lymph node metastasis and prognosis of NSCLC （ P 〈 0.05）, the expression of S1004 protein was not significantly related with histological type, sex and TNM stage （ P 〈 0.05）. Conclusion Expression of S100A4 protein was significantly associated with tumor progression, which was valuable marker predicting biological behavior and trend of metastasis of non- small - cell lung cancer.
出处
《黑龙江医学》
2006年第5期332-333,共2页
Heilongjiang Medical Journal
