摘要
采用粒子滤出／冷冻干燥复合法制备羟基丁酸与羟基辛酸共聚体[P（HB-HO）]多孔支架，并进行扫描电镜观察、孔隙率和力学性能检测以及体外降解和细胞相容性实验。结果表明，P（HB-HO）多孔支架孔隙分布均匀，连通性好，孔隙率为50％～90％时，抗压强度在1．7～6．2MPa之间，十二周体外降解率约为20％；与P（HB-HO）复合培养的小鼠成骨样细胞MC3T3-E1黏附率高，生长状态良好。证明P（HB-HO）具有良好的理化性能和细胞相容性，有望成为一种具有临床应用价值的骨组织工程支架材料。
The porous P（HB-HO） scaffold materials were prepared with particle-leaching/ freeze-drying method and were evaluated by SEM observation,porosity and mechanical assessment, degradability in vitro and cellular compatibility, The results showed that P （HB-HO） scaffold had a good pore interconnectivity with porosity 50%-90% and compressive strength 1.7-6.2MPa. Its degradation rate reached about 20% until the 12th week. MC3T3-E1 could adhere to the surface and inner wails of it,proliferated well. It was demonstrated that the new porous P（HB-HO） had superordinary physico-chemical properties and cellular compatibility ,and so it is promising to be a bone tissue engineering scaffold with clinical value.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2009年第3期459-462,466,共5页
Journal of Functional Materials
基金
国家自然科学基金资助项目(50573045)
山西省科技攻关资助项目(2006031196)
