摘要
以辛酸亚锡[Sn(Oct)2]为催化剂,聚乙二醇/L天冬氨酸预聚物[(PEGASP)n]为共引发剂,引发D,LLA和GA开环共聚合成具有功能侧氨基的PLGA(PEGASP)n共聚物。通过FTIR、1HNMR、DSC、表面接触角测定和细胞培养等方法研究共聚物的结构与性能。结果表明,共聚物为典型的非晶态聚合物;共聚物的亲水性以及对骨髓基质细胞的粘附能力和粘附效率均明显优于PLGA。
A novel biodegradable PLGA-(PEG-ASP)_n copolymer with pendant amine functional groups was synthesized by bulk ring-opening copolymerization of D,L-LA with GA using tin octoate(Sn(Oct)_2) as a catalyst, and Poly(poly(ethylene glycol)-co-L-aspartic acid)(PEG-ASP)_n prepolymer as a co-initiator. The structure and properties of the copolymer were characterized by FT-IR, ~ 1H-NMR, DSC, surfacial contact angle testing and cell culture, etc. Results showed that the PLGA-(PEG-ASP)_n was typical amorphous polymer. The hydrophilicity and the marrow stromal cell-substratum adhesion capacity and efficiency of the PLGA-(PEG-ASP)_n copolymer were evidently improved compared to that of the PLGA.
出处
《功能高分子学报》
CAS
CSCD
北大核心
2005年第2期295-298,共4页
Journal of Functional Polymers
基金
国家自然科学基金资助项目(30270393
30170270)
广东省"十五"重点项目(A302020201)
暨南大学自然科学基金资助项目(51204007)
