摘要
目的探讨金黄色葡萄球菌所致医院感染的危险因素、临床特点及耐药情况,为临床治疗金黄色葡萄球菌医院感染提供指导。方法收集确诊为金黄色葡萄球菌医院感染病例的临床资料,分析发病的危险因素及临床特点,对分离到的菌株进行药物敏感性测定。结果共73例金黄色葡萄球菌医院感染患者,均存在着严重的基础疾病,82.19%的患者接受过侵入性操作,感染部位以肺部最多见;共分离出79株金黄色葡萄球菌,包括耐甲氧西林金黄色葡萄球菌(MRSA)66株(83.54%)和甲氧西林敏感金黄色葡萄球菌(MSSA)13株(16.46%);金黄色葡萄球菌对多种抗菌药物呈普遍耐药,而MRSA的耐药性明显高于MSSA(P<0.01),未发现对耐万古霉素MRSA菌株。结论金黄色葡萄球菌医院感染常发生在有严重基础疾病、接受侵入性操作的患者,肺部感染最常见,MRSA表现为多药高度耐药,但糖肽类药物敏感性高。
OBJECTIVE To investigate the risk factors, clinical characteristics and resistance of Staphylococcus aureus nosocomial infections so as to guide the treatment of S. aureus infection. METHODS To collect clinical materials of S. aureus nosocomial infection and analyze risk factors and clinical characteristics and detect sensitivity of isolated strains to antibacterial agents. RESULTS Severe underlying diseases existed among 73 cases of S. aureus nosocomial infections, 82. 19 percent of patients had received invasive interventions. Lower respiratory tract was the most common infective site. Seventy-nine strains of S. aureus were isolated, including 66 meticillin-resistant S. aureus（MRSA） and 13 meticillin-sensitive S. aureus（MSSA）. S. aureus showed general resistance to many kinds of antibiotic drugs. The resistant rates of MRSA were much higher than those of MSSA （P〈0.01）. No strains were resistant to vancomycin. CONCLUSIONS S. aureus nosocomial infection usually occurs in the patients with severe underlying diseases and after invasive interventions. Lower respiratory tract is the most common infective site. MRSA shows multi-resistant characteristics except vancomycin with high sensitivity.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2008年第10期1485-1488,共4页
Chinese Journal of Nosocomiology
