摘要
目的探讨香蕉皮多糖对氧化损伤模型小鼠的抗氧化作用。方法D-半乳糖建立亚急性衰老小鼠模型,香蕉皮多糖按50,100,200 mg/(kg·bw)剂量灌胃,42 h后取脾脏及胸腺称重,计算脏器指数;测定血清、肝脏中丙二醛(MDA)含量及超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)的活性。结果香蕉皮多糖100,200mg/(kg·bw)剂量组小鼠体重增长量分别为(5.93±0.68),(6.10±0.23)kg,脾脏指数分别为(4.38±0.07),(4.86±0.17),胸腺指数分别为(2.55±0.13),(3.09±0.21),与模型对照组比较差异有统计学意义(P<0.01)。血清和肝脏中MDA含量明显下降(P<0.01),SOD和GSH-Px活力明显提高(P<0.01)。结论在本次实验条件下,香蕉皮多糖对氧化损伤模型小鼠有较强的拮抗作用。
Objective To study the antioxidation of banana peel polysaccharides on D - galactose induced oxidative injury in mice. Methods Mice in treatment groups were orally given banana peal polysaccharides at the dose of 50,100,200 rag/ （kg· bw） respectively. The spleen and thymus gland were separated after 42 days of the treatment to determine their indices. In addition, the malondialdehyde （MDA） contents, superoxide dismutase （SOD） and glutathione peroxidase （GSH- Px） activities in serum and liver were assayed. Results In the dose groups of 100,200 mg/（kg· bw）, body weight gain were 5.93 ± 0.68, 6.10 ± 0.23, the thymus index were 4.38 ± 0.07, 4.86 ± 0.17 and the spleen index were 2.55 ± 0.13, 3.09 ± 0.21 with significant increases （P〈 0.01）. The content of MDA significantly decreased and the activtiy of SOD and GSH - Px significantly increased both in serum and liver of mice with oxidative injury （ P 〈 0.01 ）. Conclusion The banana peel polysaccharides have significant antioxidation effect on D- galactose induced oxidative injury in mice.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2008年第11期1398-1399,共2页
Chinese Journal of Public Health
基金
辽宁省教育厅项目(05L149)
关键词
香蕉皮
多糖
抗氧化作用
banana peel
polysaccharide
antioxidation
