摘要
将Wistar大鼠随机分为7组:正常对照组,单纯照射组,复方芍根口服液正常剂量预防组(照后当天给药),复方芍根口服液大剂量预防组(照后当天给药),复方芍根口服液正常剂量治疗组(照后7天给药),复方芍根口服液大剂量治疗组(照后7天给药),西药治疗组(照后7天给药)。用60Coγ射线一次性局部照射43 Gy诱导大鼠食管炎的发生,然后采用不同方式治疗。观察各组大鼠的饮食和饮水情况,体重变化情况;于照后14天处死大鼠,进行白细胞计数及分类,制作食管的组织病理切片,观察各组大鼠食管粘膜的组织病理改变及细胞器超微结构的改变情况。结果表明,复方芍根口服液及西药对食管的放射性病理损伤均有一定治疗作用。复方芍根口服液正常剂量预防组的细胞器恢复正常。复方芍根口服液预防、治疗组与单纯照射组相比饮食量和饮水量均增加,尤以中药大剂量预防组饮食、饮水量增加明显。西药治疗组与单纯照射组相比饮食量略下降,白细胞总数、淋巴细胞分类下降。复方芍根口服液各给药组与单纯照射组相比可提高淋巴细胞百分数。复方芍根中药口服液具有治疗放射性食管炎的作用,具有在临床推广的价值。
Wistar rats were divided into seven groups： the normal group, the irradiated group, the preventive group treated with the normal dose of compound white peony root oral liquids （cWPROL） （immediately administered on the day after rats were irradiated） , the preventive group treated with the high dose of cWPROL （immediately administered on the day after rats were irradiated）, the group treated with normal dose of cWPROL （administered on the 7th day after rats were irradiated）, the group treated with high dose of cWPROL （administered on the 7th day after rats were irradiated）, the group treated with Western medicine administered from the seventh day after irradiation. The radiation esophagitis of rats was induced by single irradiation of 43 Gy gamma ray locally. Then the rats with radiation esophagitis were treated in different ways. The food weight, water volume intaked by the rats and its body weight change were observed; The rats were killed on the lgth day after irradiation and the leucocyte count and DIFF were analyzed and the esophageal pathological sections were made. The pathological change of rats＇ esophageal mucosa and uhrastructure change of cells were observed for different groups. The results showed all the cWPROL and Western medicine have therapeutic function of treating radiation-induced esophagitis of rats. The ultrastructure of cells of rats in the group treated with normal dose of cWPROL recovered. The food weight and water volume intaked by the rats had increased in the group infused with cWPROL compared with purely irradiated groups, especially in the preventive group treated with high dose of cWPROL. The weight of food, the WBC count, the lymphocyte differential count in the group which was treated with Western medicine decreased compared with the purely irradiated group. Lymphocyte differential count increased in the groups administered cWPROL compared with the purely irradiated group. The compound white peony root oral liquids serves the fuction of prevention and therapy
出处
《辐射防护》
CAS
CSCD
北大核心
2007年第4期219-227,共9页
Radiation Protection
基金
河北省科技厅科研基金资助项目(04236101D-252004-2005)
关键词
复方芍根口服液
放射性食管炎
预防
治疗
大鼠
Compound White Peony Root Oral Liquids, Radiation Esophagitis, Prevention, Treatment, Rat
