摘要
目的探讨乳腺癌组织雌激素受体(ER)、孕激素受体(PR)和c-erbB-2的表达状况及其与预后因素的相关性。方法回顾1008例乳腺癌患者的临床资料。分析乳腺癌组织ER、PR、c-erbB-2表达与患者月经状态、腋淋巴结转移情况及肿瘤TNM分期等预后因素之间的关系。结果1008例乳腺癌患者平均年龄(53.53±12.60)岁;浸润性导管癌占80.5%。绝经后ER阳性者显著多于绝经前,且临床分期较早(P<0.05);绝经前后ER/PR双阳性与双阴性者无显著性差异(P>0.05);PR阴性、ER/PR双阴性与腋淋巴结转移与否显著相关(P<0.05);ER阴性或ER/PR双阴性者的c-erbB-2阳性表达率显著高于ER阳性或ER/PR双阳性者(P<0.05)。结论ER、PR、c-erbB-2参与了乳腺癌生物学行为的调控。ER、PR表达状态与患者月经状态、腋淋巴结转移、肿瘤临床分期及c-erbB-2表达状况有关。
Objective To investigate the expression of estrogen receptor （ER）, progesterone recptor （PR） and c-erbB-2 in breast cancer tissues and its relationship with prognostic factors. Methods The clinical data of 1 008 cases with breast cancer were retrospectively analysed. The relationship between the expression of ER, PR and c-erbB-2 in breast cancer tissues and the prognostic factors such as menopausal status, axillary lymph nodes metastasis and TNM stage was investigated. Results The mean presentation age of the 1 008 cases was （53.53 ± 12.60） years. Invasive ductal cancer was the most common pathological type （80.5%）. Postmenopausal ER- positive cases were significantly more than premenopausal ER-positive ones, and the clinical stage was lower （ P 〈 0.05）. There was no significant difference between the ER/PR-positive cases and ER/PR-negative ones regardless of menopausal status. PR-negative and ER/ PR-negative cases were closely correlated with axillary lymph node metastasis （ P 〈 0.05）. The positive expression of c-erbB-2 in PR- negative or ER/PR-negative cases was significantly higher than that in PR-positive or ER/PR-positive ones （ P 〈 0.05）. Conclusion ER, PR and c-erbB-2 play an important role in modulating the biological behavior of breast cancer. The expression of ER and PR are associated with menopausal status, axillary lymph node metastasis, tumor clinical stage and c-erbB-2 expression.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2007年第6期713-715,共3页
Journal of Shanghai Jiao tong University:Medical Science
