摘要
目的对比分析影响新疆维、汉族女性乳腺癌患者腋窝淋巴结转移的危险因素。方法对309例汉族和维吾尔族临床诊断为T1期乳腺癌患者的完整临床资料进行回顾性分析，并对影响艨窝淋巴结转移的危险因素进行单因素及多因素[包括民族、年龄、月经状态、妊娠次数、产次、肿瘤部位、病理类型、雌激素受体（ER）、Ki-67等]Logistic回归分析。结果T1期维、汉族女性乳腺癌腋窝淋巴结转移率分别为43．9％、30．9％，其中腋窝淋巴结转移1～3个者维吾尔族组17例（25．8％），汉族组52例（21．4％），腋窝淋巴结转移I〉4个者维吾尔族组12例（18．2％），汉族组23例（9．5％）；Ki-67表达维吾尔族组为62．1％（41／66）汉族组为75．3％（183／243），两组比较差异均有统计学意义（均P〈0．05）；T．期维、汉族女性在妊娠次数、产次两组比较差异有统计学意义（P〈0．05）；多因素Logistic回归分析结果显示，年龄、妊娠次数、肿瘤所在象限是预测维、汉民族乳腺癌患者腋窝淋巴结转移的危险因素，而ER阳性表达是保护因素。结论T1期维吾尔族乳腺癌患者腋窝淋巴结转移率高于汉族乳腺癌患者；年龄较轻、妊娠次数较多、肿瘤所在象限位于外侧象限及乳晕区者易发生腋窝淋巴结的转移，ER阳性表达可能抑制淋巴结转移。
Objective To comparatively explore the risk factors of axillary lymph node metastasis （ALNM） in Uygur and Han patients with breast cancer. Methods A total of 243 female Han patients and 66 Uygur ones with T1 stage breast cancer were retrospectively studied by single and multi-factorial Logistic regression analysis. Results The rates of ALNM were 43.94% and 30. 86% in Uygur and Han patients respectively. There was statistic difference between them. Statistic differences existed between these two nationals in gravidity and parity. Multi-Factorial Logistic regression analysis showed that age, gravidity and quadrant of tumor localized were the risk factors of ALNM while estrogen receptor （ER） （ ＋ ） was the protective factor. Conclusions The rate of ALNM in Uygur patients with T1 stage breast cancer is higher than that in Han counterparts. More gravidity is an influencing factor. Younger age, more gravidity and location of tumor are the high risk factors for ALNM while ER （ ＋ ） is the protective factor.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2012年第10期675-678,共4页
National Medical Journal of China
关键词
乳腺肿瘤
肿瘤转移
腋窝淋巴结
维吾尔族
LOGISTIC回归
Breast neoplasms
Neoplasm metastasis
Axillary lymph node
Uygurnationality
Logistic regression model
