摘要
目的:探讨erbB-2和erbB-3表达水平与舌鳞状细胞癌发生、发展及预后的关系。方法:免疫组化检测52例舌鳞状细胞癌临床标本中erbB-2和erbB-3蛋白表达情况,研究erbB-2和erbB-3表达情况与舌鳞状细胞癌患者性别、年龄、临床分期、肿瘤大小、病理分级、淋巴转移的相关性。结果:erbB-2在舌鳞状细胞癌临床标本中的阳性表达率为67.3%,erbB-3阳性率为34.6%,erbB-2/erbB-3双阳性率为26.9%。erbB-3、erbB-2/erbB-3阳性表达均与淋巴结转移呈正相关(P=0.031,P=0.002);erbB-2表达与erbB-3表达相关;而erbB-2、erbB-3、erbB-2/erbB-3阳性表达与舌鳞状细胞癌患者性别、年龄、临床分期、肿瘤大小、病理分级无相关性。结论:erbB-2和erbB-3可能均参与了该肿瘤的发生、发展过程;erbB-3、erbB-2/erbB-3阳性表达可能与舌鳞状细胞癌生物学行为、患者淋巴结转移相关。
Objective： This study was to test the expression of erbB-2 and erbB-3 of epithelial growth factor receptor family in clinical specimens of tougue squamous cell carcinoma and to explore the role of expression of erbB-2 and erbB-3 in the carcinogenesis and development of tongue squamous cell carcinoma. Methods：Fifty-two specimens of tongue squamous cell carcinoma were tested with immumohistoehemieal assay. Then the relationship between the expression of erbB-2, erbB-3 and the gender, age of patients, clinical stage, tumor size, pathological grade and lymphatic metastasis were analyzed. Results： The positive expression ratio of erbB-2 and erbB-3 were 67.3% and 34.6%,respectively. 26.9% of tumors were positive stained both by erbB-2 and erbB-3. The expression of erbB-3, erbB-2/erbB-3 were significantly correlated with lymphatic metastasis （P = 0. 031 ,P = 0. 002）. And the correlation-ship between erbB-2 and erbB-3 was also found. Conclusion： ErbB-3 and erbB-2 may play important roles in the carcinogenesis and development of tongue squamous cell carcinoma. The positive expression of erhB-3 and erbB-2/erbB-3 were associated with the biological behavior of tumors and lymphatic metastasis of patients.
出处
《中国临床医学》
2009年第3期462-464,共3页
Chinese Journal of Clinical Medicine
基金
上海市科委重点项目(08jc1404800)
