摘要
胰岛素样生长因子Ⅰ(IGF-Ⅰ)是70个氨基酸的单链多肽,其生物学活性受IGF-Ⅰ受体及胰岛素结合蛋白的调节,它可促进细胞分化,刺激RNA、DNA的合成和细胞的增殖,促进细胞的有丝分裂及分化后功能的表达,促进脂质和糖原及蛋白质的合成等。临床上可用于生长激素不敏感综合征,1型糖尿病、2型糖尿病、极度胰岛素抵抗和慢性肾衰竭、分解代谢疾病、骨质疏松等。
Insulin-like growth factor- Ⅰ （IGF- Ⅰ ） is a single chain polypeptide which was composed of 70amino acids.Its biologic activity is regulated by IGF- Ⅰ receptor and insulin-like growth factor binding protein. IGF- Ⅰ plays a crucial role in promoting the cellular differentiation, stimulating the synthesis of RNA and DNA, encourasing the cellular mitosis and subsequent function expression, promoting syntheses of lipid, glycogen and protein and se on. IGF- Ⅰ can be used to Ireat many diseases in clinic,such as grewth hormone insensitivity syndrome,type 1 and 2 diabetes, insulin resistant, chronic renal failure, catabolism disease and osteoporosis.
出处
《医学综述》
2006年第7期396-398,共3页
Medical Recapitulate
关键词
胰岛素样生长因子Ⅰ
胰岛亲样生长园子Ⅰ受体
胰岛素结合蛋白
Insulin-like growth factor-I
Insulin-like growth factor-Ⅰ receptor
Insulin-like growth factor hinging protein
