摘要
目的探讨慢性肾功能衰竭患者血液透析前后TG F-α和IG F-Ⅱ含量变化与血液透析的关系。方法采用放射免疫分析法,检测45例慢性肾功能衰竭血液透析患者和30名正常人TGF-α和IG F-Ⅱ水平,并进行相关分析。结果患者血清TG F-α含量显著低于正常对照组(P<0.01),而透析后显著高于透析前(P<0.01);IG F-Ⅱ含量显著高于正常对照组(P<0.01),而透析前后无显著性差异(P>0.05)。患者12h尿液中TG F-α和IGF-Ⅱ含量均显著高于正常对照组(P<0.01和P<0.05)。结论TGF-α和IGF-Ⅱ两种多肽生长因子参与了机体自稳功能的调节,在慢性肾功能衰竭患者血液透析过程中,TG F-α和IGF-Ⅱ水平变化起着重要的病理生理作用。
Objective To study the relationship between homedialysis（HD） and level changes of serum transforming growth factor-α （TGF-α） and insulin-like growth factor-Ⅱ （IGF-Ⅱ ） in chronic renal failure （CRF） patients. Method Serum TGF-α and IGF-Ⅱ levels of 45 CRF patients undergoing homedialysis and 30 healthy controls were detected by radio-immunity analysis. Results Serum TGF-α levels in HD patients were distinctly lower than that of healthy controls （P〈0.01）, and increased after HD; Serum IGF-IX level were distinctly higher than that of healthy controls （P〈0.01）, but no significant changes were observed between pre- and post- dialysis（P〉0.05）.Both of TGF-α and IGF-Ⅱ levels in 12h urine were higher than that of healthy controls（P〈0.01,P〈0.05）. Conclusion Changes of TGF-α and IGF-Ⅱ level could may play an important pathophysiological role during HD.TGF-α and IGF-Ⅱ may take partin the regulation of body homestasis.
出处
《实用医药杂志》
2005年第8期683-685,共3页
Practical Journal of Medicine & Pharmacy
