摘要
目的:探讨地方性砷中毒患者细胞因子水平与抗氧化能力的相关性。方法:对81例地方性砷中毒患者(病例组)和对照组(88例)血清白细胞介素-2(IL-2)、白细胞介素-8(IL-8)、肿瘤坏死因子α(TNF-α)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)水平进行检测及分析。结果:与对照组相比,地方性砷中毒患者血清IL-2、IL-8和TNF-α水平显著增高(P<0．05),SOD、GSH-Px活性明显降低,而MDA水平增高(P<0．05)。砷中毒患者IL-2、IL-8、TNF-α含量与SOD、GSH-Px活性呈负相关性,与MDA水平呈正相关性 (P<0．05)。结论:地方性砷中毒患者血清IL-2、IL-8和TNF-α水平高于对照组,而抗氧化能力低于对照组。地方性砷中毒患者的IL-2、IL-8和TNF-α水平随抗氧化能力的降低而升高。
Objective： To study the relationship and the coordinating roles between cytokine levels and antilipid peroxidation ability in arsenism patients. Methods： Interleukin-2 （IL-2）, Interleukin-8 （IL-8）, tumornecrosis factor-α（TNF-α）, superoxide dismutase（SOD）, glutathione peroxidase（GSH-Px） and malondialdehyde（MDA） in the serum of patients were measured and analyzed. Results： Compared with those of the control, the IL-2, IL-8, TNF-α, MDA levels were higher （P〈0.05）, while the SOD, GSH-Px contents were lower （P 〈0.05） in the patients. We also found that there was a negative correlation between the IL-2, IL-8, TNF-α and SOD, GSH-Px, respectively. Further, there was a significant positive correla- tion between IL-2, IL-8, TNF-α and MDA. Conclusions： Arsenic exposure cause progressive elevation of IL-2, IL-8, TNF-α and MDA associated with decreasing level of SOD, GSH-Px.
出处
《新疆医科大学学报》
CAS
2006年第1期7-9,共3页
Journal of Xinjiang Medical University
基金
教育部高等学校博士学科点专项科研基金项目(20040760002)新疆维吾尔自治区重点学科建设基金新疆维吾尔自治区科技创新群体基金
