摘要
目的:研究喉鳞状细胞癌(LSCC)组织中细胞黏附分子CD44变构体6(CD44v6)和基质金属蛋白酶-9(MMP-9)的表达情况及临床意义。方法:应用免疫组织化学SABC法测定27例LSCC组织及8例癌旁正常喉黏膜组织中CD44v6和MMP-9的表达,并分析CD44v6和MMP-9表达与LSCC浸润、转移和预后的关系。结果:CD44v6和MMP-9在LSCC组织中均过度表达。CD44v6表达与LSCC病理分化程度、颈淋巴结转移及术后5年生存率有关(均P<0.05);MMP-9表达与LSCC颈淋巴结转移、临床分期及T分期有关(均P<0.05)。LSCC组织中CD44v6和MMP-9的表达呈显著正相关(均P<0.01)。结论:LSCC组织中CD44v6和MMP-9的表达密切相关。CD44v6和MMP-9的表达可作为临床上判断LSCC浸润、淋巴结转移及评估预后的客观指标。
Objective:To investigate the clinical implication and the expression of CD44v6 and MMP-9 protein in laryngeal squamous cell carcinoma(LSCC).Method:Twenty-seven samples of LSCC and eight biopsies of adjacent non-cancerous tissue were detected with immunohistochemical technique(SABC method).The relationship between positive expression of CD44v6 or MMP-9 in LSCC and invasion or metastasis was analyzed.Result:Both CD44v6 and MMP-9 overexpressed in LSCC.The positive expression of CD44v6 was correlated with LSCC pathologic grade,cervical lymph node metastasis and postoperation survival rate(P<0.05).The expression of MMP-9 was positively correlated with clinical staging and cervical lymph node metastasis(P<0.05).There was a significant positive correlation between the expression of CD44v6 and MMP-9(P<0.01).Conclusion:There is a relationship between the expression of CD44 and MMP-9.CD44v6 and MMP-9 might be served as an objective indicator for lymph nodal metastatic potency,tumor invasion and prognosis in LSCC.
出处
《临床耳鼻咽喉科杂志》
CSCD
北大核心
2005年第15期688-691,共4页
Journal of Clinical Otorhinolaryngology
关键词
喉肿瘤
癌
鳞状细胞
CD44抗原
基质金属蛋白酶-9
Laryngeal neoplasms
Carcinoma,squamous cell
Antigens,CD44
Matrix metalloproteinases-9
