摘要
目的研究乳腺癌组织中膜细胞骨架连接蛋白(Ezrin)、CD44v6蛋白的表达及其临床意义。方法应用免疫组化SP法,检测56例乳腺癌组织、30例癌旁正常乳腺组织中Ezrin、CD44v6的表达情况。结果 (1)乳腺癌组织中Ezrin、CD44v6的表达率分别为62.50%(35/56)、76.79%(43/56),均高于在正常乳腺组织中的阳性表达率16.67%(5/30)和23.33%(7/30),差异有统计学意义(P<0.05)。(2)Ezrin、CD44v6的表达与乳腺癌的原发肿瘤大小、组织学分级、临床TNM分期和淋巴结转移有关(P<0.05)。(3)在乳腺癌组织中Ezrin与CD44v6表达水平呈正相关(P<0.05)。结论联合检测Ezrin、CD44v6的表达有助于预测乳腺癌的恶性程度和转移潜能。
Objective To investigate the clinical significance of Ezrin、CD44v6 proteins expression in the breast carcinoma.Methods The expression of Ezrin、CD44v6 proteins was detected by immunohistochemistry in 56 cases of breast carcinoma and adjacent nontumor normal breast tissue.Results （1） The positive rates of Ezrin、CD44v6 in 56 cases of breast carcinoma were 62.50%、76.79% respectively.There was a significant difference between carcinoma and normal breast tissue（P0.05）;（2） The expression of Ezrin and CD44v6 proteins were closely related to the size of primary tumor,histological classification,clinical TNM staging and lymph node metastasis（P0.05）.（3）Ezrin、CD44v6 showed significant direct correlation with each other.Conclusion Ezrin、CD44v6 proteins expression may have significant prognostic values in assessing the degree of malignancy and potential lymph node metastasis probability in breast carcinoma.
出处
《中国实验诊断学》
北大核心
2010年第5期702-704,共3页
Chinese Journal of Laboratory Diagnosis
基金
邯郸市科学技术局资助项目(0920108055-4)
