The aggregation-caused quenching(ACQ)rationale has been employed to improve the fluorescence imaging accuracy of nanocarriers by precluding free probe-derived interferences.However,its usefulness is undermined by limi...The aggregation-caused quenching(ACQ)rationale has been employed to improve the fluorescence imaging accuracy of nanocarriers by precluding free probe-derived interferences.However,its usefulness is undermined by limited penetration and low spatiotemporal resolution of NIR-Ⅰ(700-900 nm)bioimaging owing to absorption and diffraction by biological tissues and tissue-derived autofluorescence.This study aimed to develop ACQ-based NIR-Ⅱ(1000-1700 nm)probes to further improve the imaging resolution and accuracy.The strategy employed is to install highly planar and electron-rich julolidine into the 3,5-position of aza-BODIPY based on the larger substituent effects.The newly developed probes displayed remarkable photophysical properties,with intense absorption centered at approximately 850 nm and bright emission in the 950-1300 nm region.Compared with the NIR-Ⅰ counterpart P2,the NIR-Ⅱ probes demonstrated superior water sensitivity and quenching stability.ACQ1 and ACQ6 exhibited more promising ACQ effects with absolute fluorescence quenching at water fractions above 40% and higher quenching stability with less than 2.0% fluorescence reillumination in plasma after 24 h of incubation.Theoretical calculations verified that molecular planarity is more important than hydrophobicity for ACQ properties.Additionally,in vivo and ex vivo reillumination studies revealed less than 2.5% signal interference from prequenched ACQ1,in contrast to 15% for P2.展开更多
Lanthanide(Ln^(3+))-doped near infrared(NIR)-II luminescent nanoprobes have shown great promise in many technological fields,but are currently limited by the low absorption efficiency of Ln^(3+)due to the forbidden 4f...Lanthanide(Ln^(3+))-doped near infrared(NIR)-II luminescent nanoprobes have shown great promise in many technological fields,but are currently limited by the low absorption efficiency of Ln^(3+)due to the forbidden 4f→4f transition.Herein,we report a novel NIR-II luminescent nanoprobe based on efficient energy transfer from Ce^(3+)to Er^(3+)and Nd^(3+)in sub-10 nm SrS nanocrystals(NCs),which are excitable by using a commercial blue light-emitting diode(LED).Through sensitization by the allowed 4f→5d transition of Ce^(3+),the NCs exhibit strong NIR-II luminescence from Er^(3+)and Nd^(3+)with quantum yields of 2.9%and 2.3%,respectively.Furthermore,by utilizing the intense NIR-II luminescence of Er^(3+)from the thermally coupled Stark sublevels of ^(4)I_(13/2),we demonstrate the application of SrS:Ce^(3+)/Er^(3+)NCs as blue-LED-excitable NIR-II luminescent nanoprobes for ratiometric thermal sensing.These findings reveal the unique advantages of SrS:Ln^(3+)NCs in NIR-II luminescence,which may open up a new avenue for exploring novel and versatile luminescent nanoprobes based on Ln^(3+)-doped sulphide NCs.展开更多
Aggregation-induced emission(AIE)is a photophysical phenomenon that a certain group of luminescent materials that become highly luminous when aggregated in a bad solvent or solid state.This year is the 20th anniversar...Aggregation-induced emission(AIE)is a photophysical phenomenon that a certain group of luminescent materials that become highly luminous when aggregated in a bad solvent or solid state.This year is the 20th anniversary since the AIE concept firstly proposed in 2001.Many advanced applications were gradually being explored,covering optics,electronics,energy,and bioscience and so on.At present,bibliometrics can enlighten the researchers with comprehensive sights of the achievements and trends of a specific field,which is critical for academic investigations.Herein,we presented a general bibliometric overview of AIE covering 20 years of evolution.With the assistance of Web of Science Core Collection database and several bibliometric software tools,the annual publication and citation,most influential countries/regions,most contributing authors,journals and institutions,second near-infrared(NIR-Ⅱ)related hotspots,as well as the forecast of frontiers were demonstrated and systematically analyzed.This study summarizes the current research status in AIE research field and provides a reference for future research directions.展开更多
Due to less interference in biological imaging,nanomaterials with second near-infrared(NIR-II)window(950–1700 nm)emission have received tremendous attention.However,no reports on NIR-Ⅱ electrochemiluminescence(ECL)i...Due to less interference in biological imaging,nanomaterials with second near-infrared(NIR-II)window(950–1700 nm)emission have received tremendous attention.However,no reports on NIR-Ⅱ electrochemiluminescence(ECL)imaging exist because of the lack of high-efficiency NIR-Ⅱ ECL luminophores.Herein,we designed and synthesized a NaYbF4@SiO_(2) core–shell nanoparticle for the first time.展开更多
基金supported by the National Natural Science Foundation of China(Nos.82273867 and 82030107)the Science and Technology Commission of Shanghai Municipality(No.21430760800,China).
文摘The aggregation-caused quenching(ACQ)rationale has been employed to improve the fluorescence imaging accuracy of nanocarriers by precluding free probe-derived interferences.However,its usefulness is undermined by limited penetration and low spatiotemporal resolution of NIR-Ⅰ(700-900 nm)bioimaging owing to absorption and diffraction by biological tissues and tissue-derived autofluorescence.This study aimed to develop ACQ-based NIR-Ⅱ(1000-1700 nm)probes to further improve the imaging resolution and accuracy.The strategy employed is to install highly planar and electron-rich julolidine into the 3,5-position of aza-BODIPY based on the larger substituent effects.The newly developed probes displayed remarkable photophysical properties,with intense absorption centered at approximately 850 nm and bright emission in the 950-1300 nm region.Compared with the NIR-Ⅰ counterpart P2,the NIR-Ⅱ probes demonstrated superior water sensitivity and quenching stability.ACQ1 and ACQ6 exhibited more promising ACQ effects with absolute fluorescence quenching at water fractions above 40% and higher quenching stability with less than 2.0% fluorescence reillumination in plasma after 24 h of incubation.Theoretical calculations verified that molecular planarity is more important than hydrophobicity for ACQ properties.Additionally,in vivo and ex vivo reillumination studies revealed less than 2.5% signal interference from prequenched ACQ1,in contrast to 15% for P2.
基金supported by the Science and Technology Cooperation Fund between Chinese and Australian Governments(2017YFE0132300)the National Natural Science Foundation of China(22135008,12074379,21875250,12004384)+1 种基金the Natural Science Foundation of Fujian Province(2020I0037,2021L3024)the Chinese Academy of Sciences/State Administration of Foreign Experts Affairs(CAS/SAFEA)International Partnership Program for Creative Research Teams,and Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China(2021ZR125)。
文摘Lanthanide(Ln^(3+))-doped near infrared(NIR)-II luminescent nanoprobes have shown great promise in many technological fields,but are currently limited by the low absorption efficiency of Ln^(3+)due to the forbidden 4f→4f transition.Herein,we report a novel NIR-II luminescent nanoprobe based on efficient energy transfer from Ce^(3+)to Er^(3+)and Nd^(3+)in sub-10 nm SrS nanocrystals(NCs),which are excitable by using a commercial blue light-emitting diode(LED).Through sensitization by the allowed 4f→5d transition of Ce^(3+),the NCs exhibit strong NIR-II luminescence from Er^(3+)and Nd^(3+)with quantum yields of 2.9%and 2.3%,respectively.Furthermore,by utilizing the intense NIR-II luminescence of Er^(3+)from the thermally coupled Stark sublevels of ^(4)I_(13/2),we demonstrate the application of SrS:Ce^(3+)/Er^(3+)NCs as blue-LED-excitable NIR-II luminescent nanoprobes for ratiometric thermal sensing.These findings reveal the unique advantages of SrS:Ln^(3+)NCs in NIR-II luminescence,which may open up a new avenue for exploring novel and versatile luminescent nanoprobes based on Ln^(3+)-doped sulphide NCs.
基金supported by the National Natural Science Foundation of China(62175262)the Fundamental Research Funds for the Central Universities(2020CX021)the Key R&D plan of Hunan Province(2022SK2101)。
基金National Key Research and Development Project,Grant/Award Number:2017YFC0110802Zhejiang province Key Research and Development Project,Grant/Award Number:2020C01059+3 种基金National Natural Science Foundation of China,Grant/Award Numbers:81874059,82102105,61975172,61735016Zhejiang Engineering Research Center of Cognitive Healthcare,Grant/Award Number:2017E10011National Key Scientific Instrument and Equipment Development Project,Grant/Award Number:81827804Fundamental Research Funds for the Central Universities,Grant/Award Number:2020-KYY-511108-0007。
文摘Aggregation-induced emission(AIE)is a photophysical phenomenon that a certain group of luminescent materials that become highly luminous when aggregated in a bad solvent or solid state.This year is the 20th anniversary since the AIE concept firstly proposed in 2001.Many advanced applications were gradually being explored,covering optics,electronics,energy,and bioscience and so on.At present,bibliometrics can enlighten the researchers with comprehensive sights of the achievements and trends of a specific field,which is critical for academic investigations.Herein,we presented a general bibliometric overview of AIE covering 20 years of evolution.With the assistance of Web of Science Core Collection database and several bibliometric software tools,the annual publication and citation,most influential countries/regions,most contributing authors,journals and institutions,second near-infrared(NIR-Ⅱ)related hotspots,as well as the forecast of frontiers were demonstrated and systematically analyzed.This study summarizes the current research status in AIE research field and provides a reference for future research directions.
基金the National Natural Science Foundation of China(grant no.22034003)the Excellent Research Program of Nanjing University(no.ZYJH004).
文摘Due to less interference in biological imaging,nanomaterials with second near-infrared(NIR-II)window(950–1700 nm)emission have received tremendous attention.However,no reports on NIR-Ⅱ electrochemiluminescence(ECL)imaging exist because of the lack of high-efficiency NIR-Ⅱ ECL luminophores.Herein,we designed and synthesized a NaYbF4@SiO_(2) core–shell nanoparticle for the first time.
