摘要
荧光成像作为生物医学应用中的一个常用工具,为研究人员和医师提供了一种重要的检测手段。传统的光学成像主要采用400~900 nm的荧光,但其生物组织穿透性差、背景信号高等缺点,严重限制了在生物活体成像的应用。为了改善荧光的活体成像能力,近红外二区(NIR-Ⅱ)1000~1700 nm的荧光成像逐渐被广泛关注。利用NIR-Ⅱ荧光强的组织穿透力、高信噪比等优势,光学成像在肿瘤诊断与治疗领域取得了巨大的进步,有效地提高了疾病检测的灵敏度,逐渐成为癌症早期诊断和影像导航手术的首选方案。故在此详细介绍NIR-Ⅱ荧光探针的研究现状和应用前景,以加速其研究和应用。
Fluorescence imaging,a common tool in biomedical applications,provides a crucial detecting tool for researchers and physicians.Conventional optical imaging is mainly based on fluorescence ranging from 400 to 900 nm,but the drawbacks,such as poor biological tissue penetration and high background signal,severely limit the broad bioimaging application in vivo.To improve in vivo fluorescence imaging capability,near-infraredⅡ(NIR-Ⅱ)fluorescence imaging from 1000 to 1700 nm is gradually gaining widespread attention.Taking advantage of the deep tissue penetration and high signal-to-noise ratio of NIR-Ⅱfluorescence,optical imaging has made great progress in tumor diagnosis and treatment,effectively improving the detecting sensitivity of disease and gradually becoming the preferable option for early cancer diagnosis and image-guided surgery.Therefore,the current research status and application prospects of NIR-Ⅱfluorescent probes are presented in detail to accelerate their research and application.
作者
巫浩东
余海铭
张誉荠
门昌赫
史海斌
WU Haodong;YU Haiming;ZHANG Yuji;MEN Changhe;SHI Haibin(State Key Laboratory of Radiation Medicine and Protection,School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,Soochow University,Suzhou 215123,China)
出处
《中国研究型医院》
2022年第6期10-19,共10页
Chinese Research Hospitals
基金
国家自然科学基金重大研究计划培育项目(91959123)
国家自然科学基金面上项目(22077092)
大学生创新创业训练计划项目(202010285053Z)。
关键词
荧光成像
纳米探针
肿瘤诊疗
近红外二区
Fluorescence imaging
Nanoprobes
Tumor diagnosis and treatment
Near-infraredⅡ
