摘要
具有近红外Ⅱ区荧光的Ag_(2)S量子点(QDs)因具有带隙窄、Stokes位移大及光稳定性好等优点而在生物成像领域具有广阔应用前景.然而,传统有机相合成的Ag_(2)S量子点水溶性与生物相容性较差,而水相合成Ag_(2)S量子点的荧光又很难到近红外Ⅱ区,这严重制约了Ag_(2)S量子点的生物医学应用推广.因此,优化探究具有近红外Ⅱ区荧光发射的Ag_(2)S基量子点的水相合成方法具有重要意义.采用核掺杂ZnS、表面阳离子(Zn_(2)+)改性以及调控表面配体制备出一系列Ag_(2)S基量子点,发现核掺杂和表面阳离子改性均使Ag_(2)S基量子点的荧光呈现剂量依赖性蓝移;而将表面配体由树枝状短链(Captopril)更换为长直链(11-巯基十一烷酸,MUA)时,Ag_(2)S基量子点的发射峰红移至1105 nm(近红外Ⅱ区)且半峰宽更窄.本研究发现,相比核掺杂和表面阳离子改性,优化表面配体更容易在水相中制备出具有近红外Ⅱ区荧光的Ag_(2)S基量子点.本工作为近红外荧光量子点的水相合成及优化提供了基础研究数据.
Growing numbers of quantum dots(QDs)have been applied in biological fluorescence imaging,especially those QDs with near-infrared-Ⅱfluorescence emission,avoiding the interference of autofluorescence of biological tissues,have broad application prospects in the field of fluorescence imaging.In particularly,Ag_(2)S quantum dots(Ag_(2)S QDs)have drew great attention of researchers in biological fluorescence imaging due to the near-infrared fluorescence emission,large Stokes shift,good light and chemical stability.However,the Ag_(2)S QDs synthesized in organic phase usually experienced poor water solubility and biocompatibility,while the fluorescence of the Ag_(2)S QDs synthesized in aqueous phase is difficult to reach the near-infrared-Ⅱregion,which severely restricts the promotion of Ag_(2)S QDs in biological fluorescence imaging.Therefore,it is of great significance to optimize and explore the water-phase synthesis method of Ag_(2)S based quantum dots with near-infrared-Ⅱfluorescence emission.The goal of this work is to synthesize Ag_(2)S QDs with near-infrared-Ⅱregion fluorescence emission by aqueous phase method.First,captopril modified Ag_(2)S QDs(Ag_(2)S@Cap QDs)were prepared in water,and its fluorescence emission peak lied in the near-infrared-Ⅱregion at 1005 nm.Then a series of Zn:Ag_(2)S@Cap QDs were prepared in aqueous by introducing Zn S to the Ag_(2)S core.The results showed that the fluorescence emission peaks of Zn:Ag_(2)S@Cap QDs blue shifted in a core-doping Zn S-dose dependent manner.Next,a series of Ag_(2)S@Cap-Zn QDs were prepared in aqueous by introducing Zn_(2)+to the ligand-shell of Ag_(2)S QDs.The fluorescence emission peaks of these Ag_(2)S@Cap-Zn QDs also blue shifted in a Zn_(2)+-dose dependent manner.Finally,Ag_(2)S@MUA QDs were prepared by replacing the shell ligand from Cap to 11-mercaptoundecanoic acid(MUA).The fluorescence emission peak of these Ag_(2)S@MUA QDs red shifted to 1105 nm,locating in the near-infrared-Ⅱregion,and the width of the fluorescence curve at half-maximu
作者
余梦
张子俊
朱国委
谷振华
段玉霖
余良翀
高冠斌
孙涛垒
Meng Yu;Zijun Zhang;Guowei Zhu;Zhenhua Gu;Yulin Duan;Liangchong Yu;Guanbin Gao;Taolei Sun(State Key Laboratory of Advanced Technology for Materials Synthesis and Processing,Wuhan University of Technology,Wuhan 430070;School of Chemistry,Chemical Engineering and Life Science,Wuhan University of Technology,Wuhan 430070)
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2021年第10期1281-1285,共5页
Acta Chimica Sinica
基金
国家自然科学基金(Nos.21975191,21805218,51873168)
国家级大学生创新创业训练计划(No.202110497008)资助。
