Mechanical loading is required for bone homeostasis,but the underlying mechanism is still unclear.Our previous studies revealed that the mechanical protein polycystin-1(PC1,encoded by Pkd1)is critical for bone formati...Mechanical loading is required for bone homeostasis,but the underlying mechanism is still unclear.Our previous studies revealed that the mechanical protein polycystin-1(PC1,encoded by Pkd1)is critical for bone formation.However,the role of PC1 in bone resorption is unknown.Here,we found that PC1directly regulates osteoclastogenesis and bone resorption.The conditional deletion of Pkd1 in the osteoclast lineage resulted in a reduced number of osteoclasts,decreased bone resorption,and increased bone mass.A cohort study of 32,500 patients further revealed that autosomal dominant polycystic kidney disease,which is mainly caused by loss-of-function mutation of the PKD1 gene,is associated with a lower risk of hip fracture than those with other chronic kidney diseases.Moreover,mice with osteoclastspecific knockout of Pkd1 showed complete resistance to unloading-induced bone loss.A mechanistic study revealed that PC1 facilitated TAZ nuclear translocation via the C-terminal tail-TAZ complex and that conditional deletion of Taz in the osteoclast lineage resulted in reduced osteoclastogenesis and increased bone mass.Pharmacological regulation of the PC1-TAZ axis alleviated unloading-and estrogen deficiency-induced bone loss.Thus,the PC1-TAZ axis may be a potential therapeutic target for osteoclast-related osteoporosis.展开更多
We investigated the one-dimensional diamond ladder in the momentum lattice platform. By inducing multiple twoand four-photon Bragg scatterings among specific momentum states, we achieved a flat band system based on th...We investigated the one-dimensional diamond ladder in the momentum lattice platform. By inducing multiple twoand four-photon Bragg scatterings among specific momentum states, we achieved a flat band system based on the diamond model, precisely controlling the coupling strength and phase between individual lattice sites. Utilizing two lattice sites couplings, we generated a compact localized state associated with the flat band, which remained localized throughout the entire time evolution. We successfully realized the continuous shift of flat bands by adjusting the corresponding nearest neighbor hopping strength, enabling us to observe the complete localization process. This opens avenues for further exploration of more complex properties within flat-band systems, including investigating the robustness of flat-band localized states in disordered flat-band systems and exploring many-body localization in interacting flat-band systems.展开更多
Osteoarthritis(OA),the most common joint disorder,was reported to affect 7%of the global population,and the number of people with OA has increased by almost 50%from 1990 to 2019[1].OA can occur in almost any moveable ...Osteoarthritis(OA),the most common joint disorder,was reported to affect 7%of the global population,and the number of people with OA has increased by almost 50%from 1990 to 2019[1].OA can occur in almost any moveable joint;however,the most commonly affected joints are the knee,hip,and hand.Pain,swelling,and stiffness are the most common clinical symptoms.展开更多
We demonstrate spectral-furcated vector solitons in normal-dispersion fiber lasers comprising a section of polarizationmaintaining fiber.The spectrum of each orthogonal-polarized component is confined by the birefring...We demonstrate spectral-furcated vector solitons in normal-dispersion fiber lasers comprising a section of polarizationmaintaining fiber.The spectrum of each orthogonal-polarized component is confined by the birefringence-related phasematching principle,and the bicorn spectral structure corresponds to the zero-order sidebands of two vector modes.Due to the Hopf bifurcation effect,the vector soliton evolves into a breathing state at the higher pump level,accompanied by an extra set of sub-sidebands that continuously exchange energy with the zero-order sidebands.Simulation results fully reproduce experimental observations of the spectral furcation and soliton breathing,offering comprehensive insights into the pulse-shaping mechanism of the birefringence-managed soliton.展开更多
We reported a type of strong and highly directional non-covalent interactions based on the dimerization of single-stranded helix to double-stranded helix that can achieve supramolecular polymerization, giving rise to ...We reported a type of strong and highly directional non-covalent interactions based on the dimerization of single-stranded helix to double-stranded helix that can achieve supramolecular polymerization, giving rise to the formation of linear supramolecular polymers.展开更多
基金supported by the National Key Research and Development Program of China(2019YFA0111900,2022YFC3601900 and 2022YFC2505500)the National Natural Science Foundation of China(82261160397,82272560,81922017,92149306 and 82120108009)+5 种基金the NSFC/RGC Joint Research Schemethe Research Grants Council(UGC)of the Hong Kong Special Administrative Region and the National Natural Science Foundation of China(N_CUHK483/22)the Center for Neuromusculoskeletal Restorative Medicine by Innovation and Technology Commission(ITC)of Hong Kong SAR,China(CNRM at Inno HK),the National Institutes of Health(R61-AR073518 and R01-AR071930)the Key Research and Development Program of Hunan Province(2022SK2023)the Science and Technology Innovation Program of Hunan Province(2023RC1027,2022RC1009 and 2022RC3075)the Hunan Provincial Science and Technology Department(2023JJ30896)。
文摘Mechanical loading is required for bone homeostasis,but the underlying mechanism is still unclear.Our previous studies revealed that the mechanical protein polycystin-1(PC1,encoded by Pkd1)is critical for bone formation.However,the role of PC1 in bone resorption is unknown.Here,we found that PC1directly regulates osteoclastogenesis and bone resorption.The conditional deletion of Pkd1 in the osteoclast lineage resulted in a reduced number of osteoclasts,decreased bone resorption,and increased bone mass.A cohort study of 32,500 patients further revealed that autosomal dominant polycystic kidney disease,which is mainly caused by loss-of-function mutation of the PKD1 gene,is associated with a lower risk of hip fracture than those with other chronic kidney diseases.Moreover,mice with osteoclastspecific knockout of Pkd1 showed complete resistance to unloading-induced bone loss.A mechanistic study revealed that PC1 facilitated TAZ nuclear translocation via the C-terminal tail-TAZ complex and that conditional deletion of Taz in the osteoclast lineage resulted in reduced osteoclastogenesis and increased bone mass.Pharmacological regulation of the PC1-TAZ axis alleviated unloading-and estrogen deficiency-induced bone loss.Thus,the PC1-TAZ axis may be a potential therapeutic target for osteoclast-related osteoporosis.
基金Project supported by the National Natural Science Foundation of China (Grant No.12074367)Anhui Initiative in Quantum Information Technologies,the National Key Research and Development Program of China (Grant No.2020YFA0309804)+3 种基金Shanghai Municipal Science and Technology Major Project (Grant No.2019SHZDZX01)the Strategic Priority Research Program of Chinese Academy of Sciences (Grant No.XDB35020200)Innovation Program for Quantum Science and Technology (Grant No.2021ZD0302002)New Cornerstone Science Foundation。
文摘We investigated the one-dimensional diamond ladder in the momentum lattice platform. By inducing multiple twoand four-photon Bragg scatterings among specific momentum states, we achieved a flat band system based on the diamond model, precisely controlling the coupling strength and phase between individual lattice sites. Utilizing two lattice sites couplings, we generated a compact localized state associated with the flat band, which remained localized throughout the entire time evolution. We successfully realized the continuous shift of flat bands by adjusting the corresponding nearest neighbor hopping strength, enabling us to observe the complete localization process. This opens avenues for further exploration of more complex properties within flat-band systems, including investigating the robustness of flat-band localized states in disordered flat-band systems and exploring many-body localization in interacting flat-band systems.
基金supported by the National Key Research and Development Plan(2022YFC3601900 and 2022YFC2505500)the National Natural Science Foundation of China(U21A20352)+1 种基金the Project Program of National Clinical Research Center for Geriatric Disorders(2021LNJJ06)the Natural Science Foundation of Hunan Province(2022JJ20100)。
文摘Osteoarthritis(OA),the most common joint disorder,was reported to affect 7%of the global population,and the number of people with OA has increased by almost 50%from 1990 to 2019[1].OA can occur in almost any moveable joint;however,the most commonly affected joints are the knee,hip,and hand.Pain,swelling,and stiffness are the most common clinical symptoms.
基金supported by the National Natural Science Foundation of China(No.12274344)the Natural Science Basic Research Program of Shaanxi Province(No.2021JC-09)the Fundamental Research Funds for the Central Universities(No.3102019JC008)。
文摘We demonstrate spectral-furcated vector solitons in normal-dispersion fiber lasers comprising a section of polarizationmaintaining fiber.The spectrum of each orthogonal-polarized component is confined by the birefringence-related phasematching principle,and the bicorn spectral structure corresponds to the zero-order sidebands of two vector modes.Due to the Hopf bifurcation effect,the vector soliton evolves into a breathing state at the higher pump level,accompanied by an extra set of sub-sidebands that continuously exchange energy with the zero-order sidebands.Simulation results fully reproduce experimental observations of the spectral furcation and soliton breathing,offering comprehensive insights into the pulse-shaping mechanism of the birefringence-managed soliton.
基金financially supported by the National Natural Science Foundation of China(Nos.21574054,21722403,and 21420102007)
文摘We reported a type of strong and highly directional non-covalent interactions based on the dimerization of single-stranded helix to double-stranded helix that can achieve supramolecular polymerization, giving rise to the formation of linear supramolecular polymers.
