摘要
[目的]探讨胃肠乐抗溃疡的机制及对胃黏膜细胞的保护作用。[方法]将48只大鼠随机分为正常对照组、模型对照组、胃肠乐高剂量组、胃肠乐中剂量组、胃肠乐低剂量组、洛赛克组 ;用游标尺计算各组溃疡指数 ,采用放免分析方法检测胃黏膜一氧化氮合酶(NOS)活性、降钙素基因相关肽 (CGRP)的含量。[结果]胃肠乐高、中、低剂量组及洛赛克组胃黏膜溃疡指数均较模型对照组明显下降 (P<0.01)。胃肠乐高、中、低3剂量组胃黏膜NOS活性及CGRP含量均较模型组显著升高 (P<0.01)。[结论]胃肠乐抗溃疡、促进溃疡愈合的作用机制可能与其通过增加NOS。
Objective To investigate the mechanism of anti-ulcer function and protective effect to gastric mucosa cells of Weichangle(WCL).[Methods]Fourty-eight SD rats were divided randomly in5groups:normal group,model group,WCL high-dosage group,WCL middle-dosage group,WCL low-dosage group and Omeptazole group.The index of ulcer(UI)was measured by a vernier,the activity of nitric oxide(NOS)and contents of calcitonin gene-related peptide(CGRP)were deˉtected by radioactive-immune-assay method.[Result]The UI in three kinds of dosage group of WCL and Omeptazole groups were significantly lower than those in model group(P<0.01).The activity of NOS and the contents of CGRP in three kinds of dosage group of WCL were obviously higher than those in the model group(P<0.01).[Conclusion]WCL can accelerate the healing of ulcer.The mechanisms maybe relate to its effect of promoting the activity of NOS and the increasing contents of CGRP,so as rotecting the gastric mucosa.
出处
《天津中医药》
CAS
2004年第3期240-242,共3页
Tianjin Journal of Traditional Chinese Medicine
