摘要
目的探讨结直肠息肉不同病理类型的危险因素。方法收集入院体检(包含结肠镜检查)发现结直肠息肉的患者342例,其中腺瘤型息肉172例(腺瘤型息肉组),增生型息肉81例(增生型息肉组)、炎症型息肉89例(炎症型息肉组);同期肠镜检查未见明显异常者628例为对照组。收集性别、年龄、是否吸烟、饮酒、血压、BMI、13C呼气试验结果等资料;检测血清中血糖、血脂、肝功能等代谢相关指标。比较结直肠息肉不同病理类型者与对照组的上述各指标差异。采用多因素logistic回归分析结直肠息肉不同病理类型的危险因素。结果腺瘤型息肉组与对照组性别、吸烟史、饮酒史、年龄、BMI、收缩压、舒张压、ALT、AST、ALP、γ-GT、TG、血糖等比较差异均有统计学意义(均P<0.05);增生型息肉组与对照组性别、吸烟史、饮酒史、BMI、收缩压、舒张压、γ-GT、TG等比较差异均有统计学意义(均P<0.05);炎症型息肉组与对照组吸烟、年龄、BMI、收缩压等比较差异均有统计学意义(均P<0.05)。男性、饮酒是腺瘤型息肉发生的危险因素(P<0.05或0.01),年龄<50岁人群腺瘤型息肉检出率明显低于年龄>50岁的人群(P<0.05);吸烟是增生型和炎症型息肉发生的独立危险因素(均P<0.01)。结论年龄>50岁,有吸烟、饮酒的男性是结直肠息肉(特别是腺瘤型息肉)发病的高危人群。
Objective To explore the risk factors may associated with different pathological types of colorectal polyps. Methods A total of 342 patients with colorectal polys who were admitted for physical examination(contain colonoscopy) were collected, including 172 adenomatous(adenomatous poly group), 81 hyperplastic polyps(hyperplastic polyp group) and 89 inflammations polys( inflammatory polyp group);the Control group involved 628 cases with no abnormality in colonoscopy during the same period. Collect personal data about gender,age, whether smoked or drank, blood pressure, body mass index(BMI) and 13 C Urea Breath Test. The level of blood sugar, lipids, liver function were also tested. Compare the distribution about the above index among controls and different pathological types of colorectal polyps. Using Multivariate logistic regression to analyse the risk of different pathological types of colorectal polyps. Results The gender, age, the prevalence of smoking, drinking, BMI, hypertension, ALT, AST, alkaline phosphatase, γ-GT, triglyceride(TG), blood glucose were all significantly different between the adenomatous poly group and the control group(P<0.05);The gender, the prevalence of smoking, drinking,BMI, hypertension, γ-GT, TG had significantly difference between the hyperplastic polyp group and the control group(P<0.05);The prevalence of smoking, age, BMI, systolic pressure were significantly different between the inflammation group and the control group(P<0.05).Male and drinking were independently risk factors of colorectal adenoma(P<0.05). While the Morbidity for age<50 y is lower than older population(P<0.05);Smoking was the independent risk factor for hyperplastic and inflammatory polyps. Conclusion For male aged 50 or more, had history of smoking or/and drinking was high-risk population of colorectal polyps(especially adenomatous polyp).
作者
应斐
吕丽红
应丽丽
吴建胜
YING Fei;LV Lihong;YING Lili(Department of Gastroenterology,Xianju People’s Hospital,Taizhou 317300,China)
出处
《浙江医学》
CAS
2019年第6期579-582,共4页
Zhejiang Medical Journal
关键词
结直肠息肉
危险因素
体检人群
代谢性疾病
Colorectal polyps
Risk factor
Medical examination population
Metabolic disorders
