摘要
目的探讨小肠细菌过生长(small intestinal bacterial overgrowth,SIBO)及三酰甘油(triglyceride,TG)与老年人结直肠息肉的关系及其临床意义。方法回顾性分析2018年10月—2021年1月在河北省沧州市中心医院同时行结肠镜及甲烷氢乳果糖呼气试验(lactulose breath test,LBT)检查的156例年龄≥65岁的老年结直肠息肉患者,根据结直肠息肉个数分为:单发结直肠息肉组、多发结直肠息肉组;根据结直肠息肉病理分型分为:炎性息肉组、腺瘤性息肉组;同时选取40例老年健康志愿者为健康对照组。分析比较各组的SIBO阳性率及空腹血总胆固醇(total cholesterol,TC)、TG水平。结果结直肠息肉组的TC、TG水平及SIBO阳性率高于健康对照组(P=0.035,P=0.003,P=0.001),三者在单发结直肠息肉组与多发结直肠息肉组间及炎性息肉组与腺瘤性息肉组间差异无统计学意义(P> 0.05)。SIBO阳性结直肠息肉患者的TC、TG水平高于SIBO阴性结直肠息肉患者(P=0.028,P=0.001)。高TG、SIBO阳性为结直肠息肉的危险因素。结论老年结直肠息肉患者SIBO阳性率和血TG、TC水平升高,SIBO阳性及高TG水平为老年人结直肠息肉的危险因素,可作为老年人结直肠息肉筛查及预防的重要生物学标志物。
Objectives To investigate the relationship between small intestinal bacterial overgrowth(SIBO)and triglyceride(TG)and colorectal polyps in the elderly and its clinical significance. Methods 156 elderly patients with colorectal polyps aged≥65 years who underwent colonoscopy and lactulose breath test(LBT)in Central Hospital of Cangzhou City from October2018 to January2021 were analyzed retrospectively. They were divided into single colorectal polyps group and multiple colorectal polyps group according to the number of colorectal polyps;and divided into inflammatory polyps group and adenomatous polyps group according to the pathological classification of colorectal polyps. At the same time, 40 elderly healthy volunteers were selected as the healthy control group. The positive rate of SIBO and levels of total cholesterol(TC)and TG in each group were analyzed and compared. Results The levels of TC and TG and the positive rate of SIBO in colorectal polyps group were higher than those in healthy control group(P= 0.035,P= 0.003,P= 0.001). There was no significant difference in above three indexes between single colorectal polyp group and multiple colorectal polyp group,and between inflammatory polyp group and adenomatous polyp group(P> 0.05). The levels of TC and TG in SIBO-positive patients were higher than those in SIBO-negative ones(P= 0.028,P= 0.001). High TG and SIBO positivity were risk factors of colorectal polyps. Conclusion The positive rate of SIBO and the levels of blood TG and TC increase in elderly patients with colorectal polyps. SIBO positivity and high TG level are the risk factors of colorectal polyps in the elderly,which can be used as important biomarkers for screening and prevention of colorectal polyps in the elderly.
作者
王青青
苏珊珊
魏芳
郑国启
Wang Qingqing;Su Shanshan;Wei Fang;Zheng Guoqi(Department of Gastroenterology,Cangzhou Central Hospital,Cangzhou,Hebei f061001,P.R.China)
出处
《老年医学与保健》
CAS
2022年第1期59-63,共5页
Geriatrics & Health Care
基金
河北省医学科学研究课题计划(20210924)。
关键词
老年
小肠细菌过生长
三酰甘油
结直肠息肉
甲烷氢呼气试验
elderly
small intestinal bacterial overgrowth
triglyceride
colorectal polyps
lactulose breath test
